Regulation of cell survival during renal development

被引：21
|
作者：
Hammerman, MR [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Med, Div Renal,George M OBrien Kidney & Urol Dis Ctr, St Louis, MO 63110 USA
来源：
PEDIATRIC NEPHROLOGY | 1998年 / 12卷 / 07期
关键词：
acute renal failure; apoptosis; b-cell lymphoma/leukemia gene product-2; growth factor; polycystic kidney disease;
D O I：
10.1007/s004670050513
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Apoptosis occurs in an orchestrated fashion during kidney development. In contrast, it is a relatively rare event in normal developed (adult) kidney. However, a predictable pattern of apoptosis is observed in adult kidney in two settings, during which parts of the developmental pattern are recapitulated. These are regeneration following acute ischemic injury and the process of cystogenesis in polycystic kidney disease. Apoptosis in kidney is regulated by agents both intrinsic and extrinsic to the renal cell. The protooncogene b-cell lymphoma/leukemia gene product-2 (bcl-2) is an important intrinsic factor. The growth factor epidermal growth factor is an important extrinsic regulator. A thorough understanding of the control of renal apoptosis during development and recovery from ischemic injury and in cystogenesis may lead tn new therapies to prevent or ameliorate abnormalities of kidney formation, to enhance regeneration following acute ischemic injury, and to slow the progression of renal failure in polycystic kidney disease.
引用
收藏
页码：596 / 602
页数：7
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