Regulation of eosinophil development and survival

被引:26
|
作者
Willebrand, Ralf
Voehringer, David [1 ]
机构
[1] Univ Hosp Erlangen, Dept Infect Biol, Wasserturmstr 3-5, D-91054 Erlangen, Germany
关键词
alarmins; apoptosis; eosinophils; granulocyte; monocyte colony stimulating factor; granulopoiesis; interleukin-5; COLONY-STIMULATING FACTOR; VISCERAL ADIPOSE-TISSUE; KAPPA-B-ALPHA; SIGLEC-F; DEFICIENT MICE; IN-VIVO; GASTROINTESTINAL EOSINOPHILS; DIFFERENTIATION FACTOR; CELLS; APOPTOSIS;
D O I
10.1097/MOH.0000000000000293
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of reviewEosinophils are a subset of granulocytes generally associated with type 2 immune responses. They can contribute to protection against helminths but also mediate pro-inflammatory functions during allergic immune responses. Only recently, eosinophils were also found to exert many other functions such as regulation of glucose and fat metabolism, thermogenesis, survival of plasma cells, and antitumor activity. The mechanisms that control eosinophil development and survival are only partially understood.Recent findingsHere we review new findings regarding the role of cell-extrinsic and cell-intrinsic factors for eosinophilopoiesis and eosinophil homeostasis. Several reports provide new insights in the regulation of eosinophil development by transcription factors, miRNAs and epigenetic modifications. Danger signals like lipopolysaccharide or alarmins can activate eosinophils but also prolong their lifespan. We further reflect on the observations that eosinophil development is tightly controlled by the unfolded protein stress response and formation of cytoplasmic granules.SummaryEosinophils emerge as important regulators of diverse biological processes. Their differentiation and survival is tightly regulated by factors that are still poorly understood. Newly identified pathways involved in eosinophilopoiesis and eosinophil homeostasis may lead to development of new therapeutic options for treatment of eosinophil-associated diseases.
引用
收藏
页码:9 / 15
页数:7
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