Risks and Benefits of Carnitine Supplementation in Diabetes

被引：20
|
作者：
Dambrova, M. [1 ]
Liepinsh, E. [1 ]
机构：
[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia
来源：
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2015年 / 123卷 / 02期
关键词：
L-carnitine; diabetes; food supplement; MUSCLE INSULIN-RESISTANCE; ACTIVATED RECEPTOR-GAMMA; FATTY-ACID OXIDATION; CARDIOVASCULAR-DISEASE; SKELETAL-MUSCLE; PYRUVATE-DEHYDROGENASE; MITOCHONDRIAL-FUNCTION; MYOCARDIAL-INFARCTION; MICROBIOTA METABOLISM; SECONDARY PREVENTION;
D O I：
10.1055/s-0034-1390481
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
L-carnitine is a very popular food supplement due to its safety profile, antioxidant-type activity and suggested effects on energy metabolism pathways. L-carnitine participates in both fatty acid transport pathways and the export of acetyl groups out of the mitochondria. However, contradictory data exist concerning the pharmacological outcomes of L-carnitine treatment in diabetes mellitus, which is a highly prevalent metabolic disease characterised by hyperglycemia and associated with severe complications, including cardiovascular disease and dyslipidemia. Recently, the L-carnitine-derived metabolites, acylcarnitines and trimethylamine-N-oxide, have been associated with increased cardio- metabolic risks. This review aims to highlight the possible risks and benefits of L-carnitine supplementation.
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页码：95 / 100
页数：6
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