Risks and Benefits of Carnitine Supplementation in Diabetes

被引：20

作者：

Dambrova, M. ^{[1
]}

Liepinsh, E. ^{[1
]}

机构：

[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2015年 / 123卷 / 02期

关键词：

L-carnitine; diabetes; food supplement; MUSCLE INSULIN-RESISTANCE; ACTIVATED RECEPTOR-GAMMA; FATTY-ACID OXIDATION; CARDIOVASCULAR-DISEASE; SKELETAL-MUSCLE; PYRUVATE-DEHYDROGENASE; MITOCHONDRIAL-FUNCTION; MYOCARDIAL-INFARCTION; MICROBIOTA METABOLISM; SECONDARY PREVENTION;

D O I：

10.1055/s-0034-1390481

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

L-carnitine is a very popular food supplement due to its safety profile, antioxidant-type activity and suggested effects on energy metabolism pathways. L-carnitine participates in both fatty acid transport pathways and the export of acetyl groups out of the mitochondria. However, contradictory data exist concerning the pharmacological outcomes of L-carnitine treatment in diabetes mellitus, which is a highly prevalent metabolic disease characterised by hyperglycemia and associated with severe complications, including cardiovascular disease and dyslipidemia. Recently, the L-carnitine-derived metabolites, acylcarnitines and trimethylamine-N-oxide, have been associated with increased cardio- metabolic risks. This review aims to highlight the possible risks and benefits of L-carnitine supplementation.

引用

页码：95 / 100

页数：6

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