Micro-CT characterization of human trabecular bone in osteogenesis imperfecta

被引:1
|
作者
Jameson, John [1 ,2 ]
Albert, Carolyne [1 ,2 ]
Smith, Peter [2 ,3 ]
Molthen, Robert [1 ,2 ,4 ,5 ]
Harris, Gerald [1 ,2 ,3 ]
机构
[1] Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53233 USA
[2] Orthopaed & Rehabilitat Engn Ctr, Milwaukee, WI USA
[3] Shriners Hosp Children, Chicago, IL USA
[4] Med Coll Wisconsin, Dept Med, Milwaukee, WI USA
[5] Zablocki VA Med Ctr, Dept Vet Affairs, Milwaukee, WI USA
关键词
Osteogenesis imperfecta; mu CT; bone histomorphometry; trabecular bone; trabecular structure; bone mineral density; connectivity; CHILDREN; HISTOMORPHOMETRY;
D O I
10.1117/12.877586
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Osteogenesis imperfecta (OI) is a genetic syndrome affecting collagen synthesis and assembly. Its symptoms vary widely but commonly include bone fragility, reduced stature, and bone deformity. Because of the small size and paucity of human specimens, there is a lack of biomechanical data for OI bone. Most literature has focused on histomorphometric analyses, which rely on assumptions to extrapolate 3-D properties. In this study, a micro-computed tomography (mu CT) system was used to directly measure structural and mineral properties in pediatric OI bone collected during routine surgical procedures. Surface renderings suggested a poorly organized, plate-like orientation. Patients with a history of bone-augmenting drugs exhibited increased bone volume fraction (BV/TV), trabecular number (Tb.N), and connectivity density (Eu.Conn.D). The latter two parameters appeared to be related to OI severity. Structural results were consistently higher than those reported in a previous histomorphometric study, but these differences can be attributed to factors such as specimen collection site, drug therapy, and assumptions associated with histomorphometry. Mineral testing revealed strong correlations with several structural parameters, highlighting the importance of a dual approach in trabecular bone testing. This study reports some of the first quantitative mu CT data of human OI bone, and it suggests compelling possibilities for the future of OI bone assessment.
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页数:8
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