α-aryloxy-α-methylhydrocinnamic acids:: A novel class of PPARα/γ dual agonists.

被引:0
|
作者
Xu, YP [1 ]
Brooks, DA [1 ]
Dominianni, SJ [1 ]
Etgen, G [1 ]
Jones, SB [1 ]
Kauffman, RF [1 ]
Montrose-Rafizadeh, C [1 ]
Rito, CJ [1 ]
Shuker, AJ [1 ]
Tripp, A [1 ]
Winneroski, LL [1 ]
Zink, RW [1 ]
McCarthy, J [1 ]
机构
[1] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
362-MEDI
引用
收藏
页码:U68 / U68
页数:1
相关论文
共 50 条
  • [31] Design and synthesis of novel bis-oximinoalkanoic acids as potent PPARα agonists
    Pingali, Harikishore
    Jain, Mukul
    Shah, Shailesh
    Zaware, Pandurang
    Makadia, Pankaj
    Pola, Suresh
    Thube, Baban
    Patel, Darshit
    Patil, Pravin
    Priyadarshini, Priyanka
    Suthar, Dinesh
    Shah, Maanan
    Giri, Suresh
    Patel, Pankaj
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (03) : 1156 - 1161
  • [32] Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1)
    Shibata, Yoshihiro
    Kagechika, Katsuji
    Yamaguchi, Mitsuhiro
    Kubo, Hideo
    Usui, Hiroyuki
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (23) : 7075 - 7079
  • [33] Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARα/γ dual agonists
    Kim, Eunkyung
    Park, Chan Sun
    Han, Taedong
    Bae, Myung-Ho
    Chong, Wonee
    Lee, Choong Hyun
    Shin, Young Ah
    Ahn, Byung-Nak
    Kim, Mi Kyung
    Shin, Chang Yell
    Son, Moon Ho
    Kim, Jin Kwan
    Moon, Ho Sang
    Shim, Hyun Joo
    Kim, Eun Jung
    Kim, Soon Hoe
    Lim, Joong In
    Lee, Chun Ho
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (18) : 4993 - 4996
  • [34] Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARδ agonists
    Zhang, Rui
    Wang, Aihua
    DeAngelis, Alan
    Pelton, Patricia
    Xu, Jun
    Zhu, Peifang
    Zhou, Lubing
    Demarest, Keith
    Murray, William V.
    Kuo, Gee-Hong
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (14) : 3855 - 3859
  • [35] Novel class of PPAR agonists as hypoglycemic and hypotriglycerimic agents for type II diabetes (NIDDM).
    Santini, C
    Acton, JJ
    Adams, AD
    Aster, SD
    Berger, GD
    Dadiz, A
    Graham, DW
    Gratale, DF
    Han, W
    Jones, AB
    Patel, GF
    Sidler, K
    Sahoo, SP
    Von Langen, D
    Yueh, W
    Tolman, RL
    Heck, JV
    Liebowitz, MD
    Berger, JP
    Doebber, TW
    Zhang, B
    Moller, DE
    Smith, RG
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 218 : U961 - U961
  • [36] Discovery of novel indazole derivatives as dual angiotensin II antagonists and partial PPARγ agonists
    Lamotte, Yann
    Faucher, Nicolas
    Sancon, Julien
    Pineau, Olivier
    Sautet, Stephane
    Fouchet, Marie-Helene
    Beneton, Veronique
    Tousaint, Jean-Jacques
    Saintillan, Yannick
    Ancellin, Nicolas
    Nicodeme, Edwige
    Grillot, Didier
    Martres, Paul
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (04) : 1098 - 1103
  • [37] Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists
    Zhang, Hao
    Ding, Charles Z.
    Lai, Zhi
    Chen, Sean S.
    Devasthale, Pratik
    Herpin, Tim
    Morton, George
    Qu, Fucheng
    Ryono, Denis
    Smirk, Rebecca
    Wang, Wei
    Wu, Shung
    Ye, Xiang-Xang
    Li, Yi-Xin
    Apedo, Atsu
    Farrelly, Dennis
    Wang, Tao
    Gu, Liqun
    Morgan, Nathan
    Flynn, Neil
    Chu, Cuixia
    Kunselman, Lori
    Lippy, Jonathan
    Locke, Kenneth
    O'Malley, Kevin
    Harrity, Thomas
    Cap, Michael
    Zhang, Lisa
    Hosagrahara, Vinayak
    Kadiyala, Pathanjali
    Xu, Carrie
    Doweyko, Arthur M.
    Zahler, Robert
    Hariharan, Narayanan
    Cheng, Peter T. W.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (06) : 1196 - 1205
  • [38] Synthesis and evaluation of novel α-heteroaryl-phenylpropanoic acid derivatives as PPARα/γ dual agonists
    Casimiro-Garcia, Agustin
    Bigge, Christopher F.
    Davis, Jo Ann
    Padalino, Teresa
    Pulaski, James
    Ohren, Jeffrey F.
    McConnell, Patrick
    Kane, Christopher D.
    Royer, Lori J.
    Stevens, Kimberly A.
    Auerbach, Bruce
    Collard, Wendy
    McGregor, Christine
    Song, Kun
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (20) : 7113 - 7125
  • [39] Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach
    D'Aniello, Enrico
    Fellous, Tariq
    Iannotti, Fabio Arturo
    Gentile, Alessandra
    Allara, Marco
    Balestrieri, Francesca
    Gray, Roy
    Amodeo, Pietro
    Vitale, Rosa Maria
    Di Marzo, Vincenzo
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2019, 1863 (03): : 586 - 597
  • [40] (2R)-2-ethylchromane-2-carboxylic acids:: Discovery of novel PPARα/γ dual agonists as antihyperglycemic and hypolipidemic agents
    Koyama, H
    Miller, DJ
    Boueres, JK
    Desai, RC
    Jones, AB
    Berger, JP
    MacNaul, KL
    Kelly, LJ
    Doebber, TW
    Wu, MS
    Zhou, GC
    Wang, PR
    Ippolito, MC
    Chao, YS
    Agrawal, AK
    Franklin, R
    Heck, JV
    Wright, SD
    Moller, DE
    Sahoo, SP
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (12) : 3255 - 3263