Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARδ agonists

被引：16
|
作者：
Zhang, Rui [1 ]
Wang, Aihua [1 ]
DeAngelis, Alan [1 ]
Pelton, Patricia [1 ]
Xu, Jun [1 ]
Zhu, Peifang [1 ]
Zhou, Lubing [1 ]
Demarest, Keith [1 ]
Murray, William V. [1 ]
Kuo, Gee-Hong [1 ]
机构：
[1] Johnson & Johnson Pharmaceut Res & Dev, LLC, Cranbury, NJ 08512 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 14期
关键词：
PPAR delta agonists; Y-shaped molecules; dyslipidemic;
D O I：
10.1016/j.bmcl.2007.05.007
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel series of potent and selective PPAR delta agonists, para-alkylthiophenoxyacetic acids, was identified. The synthesis and structure-activity relationships are described. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3855 / 3859
页数：5
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