Pharmacokinetics of lactosaminated recombinant human growth hormone in mice

AIM: To study the pharmacokinetic characteristics of lactosaminated recombinant human growth hormone (hGH-L) in mice. METHODS: The biodistribution was studied with in vivo radioactive tracer technique. The pharmacokinetics was investigated by radioimmunoassy (RIA) method of hGH-L. The results were compared with that of recombinant human growth hormone (hGH). RESULTS: I-125-hGH-L has remarkable livertaxis. The area under drug concentration-time curve (32686.9 mug . min . L-1) in blood and serum mean residence time (21.4 min) of hGH-L are less than that of hGH (36913. 1 mug . min . L-1 and 24. 9 min) (P < 0.05). In target organ liver, hGH-L distribution half life (1.8 min) and elimination half life (11.1 min) are shorter than that of hGH (2.1 min and 27.7 min) (P < 0.05). The area under drug concentration-time curve (11621.9 mug . min L-1) of hGH-L is bigger than that of hGH (12148. 2 mug . min . L-1) (P < 0. 05) in liver. CONCLUSION: The pharmacokinetic paramters of hGH-L has obvious advantage over that of hGH.