Pharmacokinetics of lactosaminated recombinant human growth hormone in mice

被引：0

作者：

Li, YC ^{[1
]}

Guan, CT

Zhao, KQ

Chen, ZL

Li, TL

机构：

[1] Sichuan Univ, W China Med Ctr, Affiliated Hosp 1, Dept Nucl Med, Chengdu 610041, Peoples R China

[2] Sichuan Normal Univ, Dept Chem, Chengdu 610066, Peoples R China

[3] Sichuan Univ, W China Med Ctr, Coll Pharm, Chengdu 610041, Peoples R China

[4] Sichuan Univ, W China Med Ctr, Affiliated Hosp 1, Dept Pharm, Chengdu 610041, Peoples R China

来源：

ACTA PHARMACOLOGICA SINICA | 2001年 / 22卷 / 05期

关键词：

somatotropin; pharmacokinetics; recombinant proteins;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

AIM: To study the pharmacokinetic characteristics of lactosaminated recombinant human growth hormone (hGH-L) in mice. METHODS: The biodistribution was studied with in vivo radioactive tracer technique. The pharmacokinetics was investigated by radioimmunoassy (RIA) method of hGH-L. The results were compared with that of recombinant human growth hormone (hGH). RESULTS: I-125-hGH-L has remarkable livertaxis. The area under drug concentration-time curve (32686.9 mug . min . L-1) in blood and serum mean residence time (21.4 min) of hGH-L are less than that of hGH (36913. 1 mug . min . L-1 and 24. 9 min) (P < 0.05). In target organ liver, hGH-L distribution half life (1.8 min) and elimination half life (11.1 min) are shorter than that of hGH (2.1 min and 27.7 min) (P < 0.05). The area under drug concentration-time curve (11621.9 mug . min L-1) of hGH-L is bigger than that of hGH (12148. 2 mug . min . L-1) (P < 0. 05) in liver. CONCLUSION: The pharmacokinetic paramters of hGH-L has obvious advantage over that of hGH.

引用

页码：450 / 454

页数：5

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