On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity

被引：56

作者：

Elrashdy, Fatma ^{[1
]}

Aljaddawi, Abdullah A. ^{[2
]}

Redwan, Elrashdy M. ^{[2
]}

Uversky, Vladimir N. ^{[2
,3
,4
,5
]}

机构：

[1] Cairo Univ, Kasr Alainy Sch Med, Dept Endem Med & Hepatogastroenterol, Cairo, Egypt

[2] King Abdulaziz Univ, Fac Sci, Biol Sci Dept, Jeddah 21589, Saudi Arabia

[3] Univ S Florida, Dept Mol Med, Morsani Coll Med, Tampa, FL 33620 USA

[4] Univ S Florida, USF Hlth Byrd Alzheimers Res Inst, Morsani Coll Med, Tampa, FL 33620 USA

[5] Russian Acad Sci, Inst Biol Instrumentat, Fed Res Ctr, Pushchino Sci Ctr Biol Res, Pushchino, Russia

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 2021年 / 39卷 / 15期

关键词：

SARS-CoV-2; COVID-19; reinfection; exosome; extracellular vesicle; ACUTE RESPIRATORY SYNDROME; SARS-CORONAVIRUS; EXTRACELLULAR VESICLES; ULTRASTRUCTURAL CHARACTERIZATION; MEMBRANE-VESICLES; REPLICATION; INFECTION; PATHOGENESIS; PATHOLOGY; LUNG;

D O I：

10.1080/07391102.2020.1790426

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We propose here that one of the potential mechanisms for the relapse of the COVID-19 infection could be a cellular transport pathway associated with the release of the SARS-CoV-2-loaded exosomes and other extracellular vesicles. It is possible that this "Trojan horse" strategy represents possible explanation for the re-appearance of the viral RNA in the recovered COVID-19 patients 7-14 day post discharge, suggesting that viral material was hidden within such exosomes or extracellular vesicles during this "silence" time period and then started to re-spread again. Communicated by Ramaswamy H. Sarma

引用

页码：5831 / 5842

页数：12

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