On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity

被引：56
|
作者：
Elrashdy, Fatma [1 ]
Aljaddawi, Abdullah A. [2 ]
Redwan, Elrashdy M. [2 ]
Uversky, Vladimir N. [2 ,3 ,4 ,5 ]
机构：
[1] Cairo Univ, Kasr Alainy Sch Med, Dept Endem Med & Hepatogastroenterol, Cairo, Egypt
[2] King Abdulaziz Univ, Fac Sci, Biol Sci Dept, Jeddah 21589, Saudi Arabia
[3] Univ S Florida, Dept Mol Med, Morsani Coll Med, Tampa, FL 33620 USA
[4] Univ S Florida, USF Hlth Byrd Alzheimers Res Inst, Morsani Coll Med, Tampa, FL 33620 USA
[5] Russian Acad Sci, Inst Biol Instrumentat, Fed Res Ctr, Pushchino Sci Ctr Biol Res, Pushchino, Russia
来源：
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 2021年 / 39卷 / 15期
关键词：
SARS-CoV-2; COVID-19; reinfection; exosome; extracellular vesicle; ACUTE RESPIRATORY SYNDROME; SARS-CORONAVIRUS; EXTRACELLULAR VESICLES; ULTRASTRUCTURAL CHARACTERIZATION; MEMBRANE-VESICLES; REPLICATION; INFECTION; PATHOGENESIS; PATHOLOGY; LUNG;
D O I：
10.1080/07391102.2020.1790426
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We propose here that one of the potential mechanisms for the relapse of the COVID-19 infection could be a cellular transport pathway associated with the release of the SARS-CoV-2-loaded exosomes and other extracellular vesicles. It is possible that this "Trojan horse" strategy represents possible explanation for the re-appearance of the viral RNA in the recovered COVID-19 patients 7-14 day post discharge, suggesting that viral material was hidden within such exosomes or extracellular vesicles during this "silence" time period and then started to re-spread again. Communicated by Ramaswamy H. Sarma
引用
收藏
页码：5831 / 5842
页数：12
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