On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity

被引：56
|
作者：
Elrashdy, Fatma [1 ]
Aljaddawi, Abdullah A. [2 ]
Redwan, Elrashdy M. [2 ]
Uversky, Vladimir N. [2 ,3 ,4 ,5 ]
机构：
[1] Cairo Univ, Kasr Alainy Sch Med, Dept Endem Med & Hepatogastroenterol, Cairo, Egypt
[2] King Abdulaziz Univ, Fac Sci, Biol Sci Dept, Jeddah 21589, Saudi Arabia
[3] Univ S Florida, Dept Mol Med, Morsani Coll Med, Tampa, FL 33620 USA
[4] Univ S Florida, USF Hlth Byrd Alzheimers Res Inst, Morsani Coll Med, Tampa, FL 33620 USA
[5] Russian Acad Sci, Inst Biol Instrumentat, Fed Res Ctr, Pushchino Sci Ctr Biol Res, Pushchino, Russia
来源：
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 2021年 / 39卷 / 15期
关键词：
SARS-CoV-2; COVID-19; reinfection; exosome; extracellular vesicle; ACUTE RESPIRATORY SYNDROME; SARS-CORONAVIRUS; EXTRACELLULAR VESICLES; ULTRASTRUCTURAL CHARACTERIZATION; MEMBRANE-VESICLES; REPLICATION; INFECTION; PATHOGENESIS; PATHOLOGY; LUNG;
D O I：
10.1080/07391102.2020.1790426
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We propose here that one of the potential mechanisms for the relapse of the COVID-19 infection could be a cellular transport pathway associated with the release of the SARS-CoV-2-loaded exosomes and other extracellular vesicles. It is possible that this "Trojan horse" strategy represents possible explanation for the re-appearance of the viral RNA in the recovered COVID-19 patients 7-14 day post discharge, suggesting that viral material was hidden within such exosomes or extracellular vesicles during this "silence" time period and then started to re-spread again. Communicated by Ramaswamy H. Sarma
引用
收藏
页码：5831 / 5842
页数：12
相关论文
共 50 条
  • [1] Reactivation or reinfection of COVID-19 disease?
    Ozdemir, Oner
    [J]. JOURNAL OF MEDICAL VIROLOGY, 2022, 94 (01) : 17 - 17
  • [2] COVID-19 reinfection or reactivation in a renal transplant patient
    Abolghasemi, Sara
    Zolfaghari, Farnaz
    Naeimipoor, Mohammad
    Tehrani, Hamed Azhdari
    Hakamifard, Atousa
    [J]. CLINICAL CASE REPORTS, 2021, 9 (08):
  • [3] Risk of reactivation or reinfection of novel coronavirus (COVID-19)
    Alizargar, Javad
    [J]. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2020, 119 (06) : 1123 - 1123
  • [4] HYPOTHESES FOR REACTIVATION RECURRENCE AND REINFECTION RECURRENCE OF COVID-19
    Yazdani, Razieh
    Shams, Amir
    Iravani, Omid
    Ghaedi, Kamran
    Forootan, Farzad S.
    [J]. APPLIED BIOLOGICAL RESEARCH, 2021, 23 (04) : 311 - 321
  • [5] Contentious Issue in Recurrent COVID-19 Infection: Reactivation or Reinfection
    Sen, Manas Kamal
    Gupta, Nitesh
    Yadav, Siddharth Raj
    Kumar, Rohit
    Singh, Balvinder
    Ish, Pranav
    [J]. TURKISH THORACIC JOURNAL, 2020, 21 (06): : 463 - 466
  • [6] Proper Assignation of Reactivation in a COVID-19 Recurrence Initially Interpreted as a Reinfection
    Perez-Lago, Laura
    Martinez-Lozano, Helena
    Pajares Diaz, Jose Antonio
    Diaz Gomez, Arantxa
    Machado, Marina
    Sola-Campoy, Pedro J.
    Herranz, Marta
    Buenestado-Serrano, Sergio
    Valerio, Maricela
    Olmedo, Maria
    Andres Zayas, Cristina
    Comas, Inaki
    Gonzalez Candelas, Fernando
    Banares, Rafael
    Catalan, Pilar
    Munoz, Patricia
    Garcia de Viedma, Dario
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2021, 224 (05): : 788 - 792
  • [7] COVID-19 Reinfection
    Habadi, Mohammed, I
    Abdalla, Tarig H. Balla
    Hamza, Nashaat
    Al-Gedeei, Afnan
    [J]. CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (01)
  • [8] The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge
    Yan, Yan-yan
    Zhou, Wen-min
    Wang, Yu-qing
    Guo, Qiao-ru
    Zhao, Fu-xi
    Zhu, Zhuang-yan
    Xing, Yan-xia
    Zhang, Hai-yan
    Aljofan, Mohamad
    Jarrahi, Alireza Mosavi
    Makabel, Bolat
    Zhang, Jian-ye
    [J]. FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 8
  • [9] Second COVID-19 infection in a patient with multiple myeloma in Brazil - reinfection or reactivation?
    Bellesso, Marcelo
    Bruniera, Felipe Ribeiro
    Trunkel, Ariel Testasicca
    Nicodemo, Izabel Pernambuco
    [J]. HEMATOLOGY TRANSFUSION AND CELL THERAPY, 2021, 43 (01) : 109 - 111
  • [10] Is reinfection negligible effect in COVID-19? A mathematical study on the effects of reinfection in COVID-19
    Tamilalagan, P.
    Krithika, B.
    Manivannan, P.
    Karthiga, S.
    [J]. MATHEMATICAL METHODS IN THE APPLIED SCIENCES, 2023, 46 (18) : 19115 - 19134
12345