Micro(RNA) Managing by mTORC1

被引：7
|
作者：
Jewell, Jenna L. [1 ,2 ]
Flores, Fabian [1 ,2 ]
Guan, Kun-Liang [1 ,2 ]
机构：
[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
来源：
MOLECULAR CELL | 2015年 / 57卷 / 04期
关键词：
RAPAMYCIN; MICRORNAS;
D O I：
10.1016/j.molcel.2015.02.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this issue of Molecular Cell, Ye et al. (2015) demonstrate that mTORC1 globally regulates miRNA biogenesis under nutrient-rich conditions via the E3 ubiquitin ligase Mdm2, which promotes Drosha degradation.
引用
收藏
页码：575 / 576
页数：2
相关论文
共 50 条
  • [41] Regulation of mTORC1 Signaling by pH
    Balgi, Aruna D.
    Diering, Graham H.
    Donohue, Elizabeth
    Lam, Karen K. Y.
    Fonseca, Bruno D.
    Zimmerman, Carla
    Numata, Masayuki
    Roberge, Michel
    PLOS ONE, 2011, 6 (06):
  • [42] Crosstalk of Hedgehog and mTORC1 Pathways
    Larsen, Lasse Jonsgaard
    Moller, Lisbeth Birk
    CELLS, 2020, 9 (10) : 1 - 21
  • [43] How mTORC1 senses leucine
    Baumann, Kim
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2015, 16 (12) : 699 - 699
  • [44] A Wacky Bridge to mTORC1 Dimerization
    Montagne, Jacques
    DEVELOPMENTAL CELL, 2016, 36 (02) : 129 - 130
  • [45] mTORC1/mTORC2 SIGNALING IN PILOCYTIC ASTROCYTOMA
    Hutt, Marianne
    Karajannis, Matthias A.
    Shah, Smit
    Eberhart, Charles G.
    Raabe, Eric
    Rodriguez, Fausto J.
    NEURO-ONCOLOGY, 2013, 15 : 48 - 48
  • [46] How mTORC1 senses leucine
    Kim Baumann
    Nature Reviews Molecular Cell Biology, 2015, 16 : 699 - 699
  • [47] Regulation of mTORC1 by amino acids
    Bar-Peled, Liron
    Sabatini, David M.
    TRENDS IN CELL BIOLOGY, 2014, 24 (07) : 400 - 406
  • [48] Controlling mTORC1 activity as a novel therapeutic strategy for managing human hair growth and pigmentation
    Suzuki, T.
    Cheret, J.
    Scala, F. D.
    Gherardini, J.
    O'Sullivan, J.
    Epstein-Kuka, G.
    Bauman, A. J.
    Demetriades, C.
    Paus, R.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022, 142 (08) : S112 - S112
  • [49] OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR
    Zhao, Linlin
    Wang, Xinbo
    Yu, Yue
    Deng, Lu
    Chen, Lei
    Peng, Xiaoping
    Jiao, Chenchen
    Gao, Guoli
    Tan, Xiao
    Pan, Weijuan
    Ge, Xin
    Wang, Ping
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (13) : 4883 - 4892
  • [50] mTORC1 as the main gateway to autophagy
    Rabanal-Ruiz, Yoana
    Otten, Elsje G.
    Korolchuk, Viktor I.
    SIGNALLING MECHANISMS IN AUTOPHAGY, 2017, 61 (06): : 565 - 584
12345