Micro(RNA) Managing by mTORC1

被引：7
|
作者：
Jewell, Jenna L. [1 ,2 ]
Flores, Fabian [1 ,2 ]
Guan, Kun-Liang [1 ,2 ]
机构：
[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
来源：
MOLECULAR CELL | 2015年 / 57卷 / 04期
关键词：
RAPAMYCIN; MICRORNAS;
D O I：
10.1016/j.molcel.2015.02.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this issue of Molecular Cell, Ye et al. (2015) demonstrate that mTORC1 globally regulates miRNA biogenesis under nutrient-rich conditions via the E3 ubiquitin ligase Mdm2, which promotes Drosha degradation.
引用
收藏
页码：575 / 576
页数：2
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