Synthesis and morpholinolysis of N,N-diethyl carbamate derivatives of 4-HOAt, 7-HOAt and HOBt

被引：6
|
作者：
Khattab, Sherine N. [1 ]
Hassan, Seham Y. [1 ]
Hamed, Ezzat A. [1 ]
El-Faham, Ayman [1 ]
机构：
[1] Univ Alexandria, Fac Sci, Dept Chem, Alexandria 21321, Egypt
来源：
JOURNAL OF CHEMICAL RESEARCH | 2007年 / 04期
关键词：
1-hydroxy-7-azabenzotriazole (7-HOAt); 1-hydroxy-4-azabenzotriazole (4-HOAt); 1-hydroxybenzotriazole (HOBt); morpholinolysis; morpholin-1-yl carbamate derivatives; four-membered transition state;
D O I：
10.3184/030823407X209688
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
N,N-Diethyl carbarnates of 1-hydroxy-7-azabenzotriazole (7-HOAt), 1-hydroxy-4-azabenzotriazole (4-HOAt), 1-hydroxybenzotriazole (HOBO, and 1-hydroxypyrrolidine-2,5-dione have been synthesised. The reactivities of these active esters have been determined by studying the kinetics and mechanism of their morpholinolysis in acetonitrile at different temperatures.
引用
收藏
页码：247 / 251
页数：5
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