Synthesis, Biological Activity, and Crystal Structure of N,N-Diethyl-2-{[7-methoxy-4-(phenylamino)quinazolin-6-yl]oxy}acetamide Derivatives

被引：3

作者：

Han, Xiao ^{[1
]}

Cai, Zhi-qiang ^{[1
]}

Wu, Li-hua ^{[2
]}

Hou, Ling ^{[1
]}

Li, Shuai ^{[3
]}

机构：

[1] Shenyang Univ Technol, Liaoning Prov Profess & Tech Innovat Ctr Fine Che, Sch Petrochem Engn, Shenyang 111003, Liaoning, Peoples R China

[2] Shandong Ctr Food & Drug Evaluat & Inspect, Jinan 250101, Shandong, Peoples R China

[3] Inst Phamaceut Sci Shandong Prov, Key Lab Chem Drug Res Shandong Prov, Jinan 250101, Shandong, Peoples R China

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2021年 / 91卷 / 11期

关键词：

quinazoline derivatives; synthesis; X-ray diffraction; antitumor activity; QUINAZOLINE; DESIGN;

D O I：

10.1134/S1070363221110165

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A number of novel 4-aminoquinazoline derivatives has been synthesized by four-step synthesis. Structures of the synthesized compounds have been characterized by IR and H-1 NMR spectra, element analysis, and single crystal X-ray diffraction. Biological activity of the products has been tested and most of those are characterized by potential antitumor activity against MKN45 cell line. Two compounds exhibit significant inhibitory activity higher than that of Gefitinib used as the positive control. Preliminary structure-activity relationship is considered.

引用

页码：2286 / 2291

页数：6

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