Challenges of Detecting Bioterrorism Agents in Complex Matrices

被引：0
|
作者：
Hartmann, Erica M. [2 ]
Halden, Rolf U. [1 ]
机构：
[1] Arizona State Univ, Sch Sustainable Engn & Built Environm, Biodesign Inst, 1001 S McAllister Ave, Tempe, AZ 85287 USA
[2] Arizona State Univ, Biodesign Inst, Tempe, AZ USA
来源：
DETECTION OF BIOLOGICAL AGENTS FOR THE PREVENTION OF BIOTERRORISM | 2010年
关键词：
Environmental samples; Clinical samples; Norovirus; Stool; ASSISTED-LASER-DESORPTION/IONIZATION; FLIGHT MASS-SPECTROMETRY; ESCHERICHIA-COLI; PROTEOMICS; IDENTIFICATION; PROTEINS; TIME; ELECTROPHORESIS; ELECTROSPRAY; PEPTIDES;
D O I：
10.1007/978-90-481-9815-3_10
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This chapter offers an overview of the shift from the use of mass spectrometry for studying purified bioterrorism agents to the development of methods for rapid detection thereof in environmental and clinical samples. We discuss the difficulties of working with such complex matrices and present methods for quickly and effectively reducing complexity through sample preparation. Finally, we examine a success story wherein the common pathogen and potential bioterrorism agent norovirus is detected at clinically relevant levels in human stool.
引用
收藏
页码：149 / +
页数：3
相关论文
共 50 条
  • [31] Bioterrorism: Confronting a complex threat
    Freedman, Lawrence D.
    FOREIGN AFFAIRS, 2008, 87 (01) : 181 - 181
  • [32] Antitoxins: novel strategies to target agents of bioterrorism
    G. Jonah A. Rainey
    John A. T. Young
    Nature Reviews Microbiology, 2004, 2 : 721 - 726
  • [33] Detecting biowarfare weapons - Developing systems to combat bioterrorism
    Dutton, G
    GENETIC ENGINEERING NEWS, 2001, 21 (19): : 1 - +
  • [34] Training laboratory personnel to identify the agents of bioterrorism
    Barden, LS
    Delany, JR
    Glenn, S
    Perry, SR
    Lipman, H
    Escott, SH
    Luck, D
    LABORATORY MEDICINE, 2002, 33 (09) : 699 - 703
  • [35] INTRODUCTION: DETECTION DETECTING BIOTERRORISM: HOW TO DETECT THE UNEXPECTED?
    Wielinga, Peter R.
    BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE, 2013, 11 : S123 - S123
  • [36] Sampling uncertainties for the detection of chemical agents in complex food matrices
    Whitaker, TB
    Johansson, AS
    JOURNAL OF FOOD PROTECTION, 2005, 68 (06) : 1306 - 1313
  • [37] Antitoxins: Novel strategies to target agents of bioterrorism
    Rainey, GJA
    Young, JAT
    NATURE REVIEWS MICROBIOLOGY, 2004, 2 (09) : 721 - 726
  • [38] Bacterial pathogens as biological weapons and agents of bioterrorism
    Greenfield, RA
    Drevets, DA
    Machado, LJ
    Voskuhl, GW
    Bronze, MS
    AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2002, 323 (06): : 299 - 315
  • [39] Bioterrorism: Viral agents as weapons of mass destruction
    Grieder, FB
    Schoneboom, BA
    Multidisciplinarity for Parasites, Vectors and Parasitic Diseases, Vol 1, 2004, : 11 - 16
  • [40] The ABCs of bioterrorism for veterinarians, focusing on Category A agents
    Davis, RG
    JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2004, 224 (07): : 1084 - 1095
12345