Challenges of Detecting Bioterrorism Agents in Complex Matrices

被引：0
|
作者：
Hartmann, Erica M. [2 ]
Halden, Rolf U. [1 ]
机构：
[1] Arizona State Univ, Sch Sustainable Engn & Built Environm, Biodesign Inst, 1001 S McAllister Ave, Tempe, AZ 85287 USA
[2] Arizona State Univ, Biodesign Inst, Tempe, AZ USA
来源：
DETECTION OF BIOLOGICAL AGENTS FOR THE PREVENTION OF BIOTERRORISM | 2010年
关键词：
Environmental samples; Clinical samples; Norovirus; Stool; ASSISTED-LASER-DESORPTION/IONIZATION; FLIGHT MASS-SPECTROMETRY; ESCHERICHIA-COLI; PROTEOMICS; IDENTIFICATION; PROTEINS; TIME; ELECTROPHORESIS; ELECTROSPRAY; PEPTIDES;
D O I：
10.1007/978-90-481-9815-3_10
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This chapter offers an overview of the shift from the use of mass spectrometry for studying purified bioterrorism agents to the development of methods for rapid detection thereof in environmental and clinical samples. We discuss the difficulties of working with such complex matrices and present methods for quickly and effectively reducing complexity through sample preparation. Finally, we examine a success story wherein the common pathogen and potential bioterrorism agent norovirus is detected at clinically relevant levels in human stool.
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页码：149 / +
页数：3
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