Determination of ciprofloxacin in plasma and urine by HPLC with ultraviolet detection

被引：0

作者：

Kamberi, M ^{[1
]}

Tsutsumi, K ^{[1
]}

Kotegawa, T ^{[1
]}

Nakamura, K ^{[1
]}

Nakano, S ^{[1
]}

机构：

[1] Oita Med Univ, Dept Clin Pharmacol & Therapeut, Oita 87955, Japan

来源：

CLINICAL CHEMISTRY | 1998年 / 44卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

A simple, sensitive isocratic method for the detection and quantification of ciprofloxacin in plasma and urine has been developed. The assay consisted of reversed-phase HPLC with ultraviolet detection. Plasma proteins were removed by a fast and efficient procedure. For the urine samples, the only required sample preparation was dilution. Separation was achieved on a C-18 reversed-phase column. The quantification limit was 0.01 mg/L in plasma and 0.5 mg/L in urine. This method was sufficiently sensitive for pharmacokinetic studies.

引用

页码：1251 / 1255

页数：5

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