Preclinical identification of AZD7762, a novel, potent and selective inhibitor of Checkpoint kinases

被引:0
|
作者
Ashwell, Susan [1 ]
Caleb, Benjamin L. [1 ]
Deng, Chun [1 ]
Green, Stephen [2 ]
Grondine, Michael R. [1 ]
Haye, Heather R. [2 ]
Horn, Candice L. [1 ]
Janetka, James W.
Liu, Dongfang [1 ]
Mouchet, Elizabeth [2 ]
Ready, Shannon [1 ]
Rosenthal, Judith L. [1 ]
Queva, Christophe [1 ]
Taylor, Karen J. [2 ]
Sheehy, Adam M. [1 ]
Walker, Graeme E. [2 ]
White, Anne M. [2 ]
Zabludoff, Sonya D. [1 ]
机构
[1] AstraZeneca, Waltham, MA USA
[2] AstraZeneca, Macclesfield, Cheshire, England
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:3411S / 3411S
页数:1
相关论文
共 50 条
  • [41] Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3
    Noori, Mahboubeh S.
    Bhatt, Pooja M.
    Courreges, Maria C.
    Ghazanfari, Davoud
    Cuckler, Chaz
    Orac, Crina M.
    McMills, Mark C.
    Schwartz, Frank L.
    Deosarkar, Sudhir P.
    Bergmeier, Stephen C.
    McCall, Kelly D.
    Goetz, Douglas J.
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2019, 317 (06): : C1289 - C1303
  • [42] AZD4625 is a Potent and Selective Inhibitor of KRASG12C
    Chakraborty, Atanu
    Hanson, Lyndsey
    Robinson, David
    Lewis, Hilary
    Bickerton, Sue
    Davies, Michael
    Polanski, Radoslaw
    Whiteley, Rebecca
    Koers, Alex
    Atkinson, James
    Baker, Tamara
    Barrantes, Ivan del Barco
    Ciotta, Giovanni
    Kettle, Jason G.
    Magiera, Lukasz
    Martins, Carla P.
    Peter, Alison
    Wigmore, Eleanor
    Underwood, Zoe
    Cosulich, Sabina
    Niedbala, Michael
    Ross, Sarah
    MOLECULAR CANCER THERAPEUTICS, 2022, 21 (10) : 1535 - 1546
  • [43] IDENTIFICATION AND CHARACTERIZATION OF A POTENT, SELECTIVE KATII INHIBITOR
    Strick, Christine
    Campbell, B.
    Culp, J.
    Dounay, A.
    Fonseca, K.
    Hawrylik, S.
    Hayward, M.
    Horner, W.
    Hughes, Z.
    James, Larry
    Loulakis, P.
    McGinnis, D.
    Salafia, M.
    Seymour, P.
    Sneed, B.
    Stratman, N.
    Stutzman-Engwall, K.
    Valentine, J.
    Verhoest, P.
    Wang, H.
    Zawadzke, L.
    Zhao, H.
    SCHIZOPHRENIA BULLETIN, 2011, 37 : 113 - 114
  • [44] AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia
    Keeton, Erika K.
    McEachern, Kristen
    Dillman, Keith S.
    Palakurthi, Sangeetha
    Cao, Yichen
    Grondine, Michael R.
    Kaur, Surinder
    Wang, Suping
    Chen, Yuching
    Wu, Allan
    Shen, Minhui
    Gibbons, Francis D.
    Lamb, Michelle L.
    Zheng, Xiaolan
    Stone, Richard M.
    DeAngelo, Daniel J.
    Platanias, Leonidas C.
    Dakin, Les A.
    Chen, Huawei
    Lyne, Paul D.
    Huszar, Dennis
    BLOOD, 2014, 123 (06) : 905 - 913
  • [45] Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas
    Oza, Vibha
    Ashwell, Susan
    Almeida, Lynsie
    Brassil, Patrick
    Breed, Jason
    Deng, Chun
    Gero, Thomas
    Grondine, Michael
    Horn, Candice
    Ioannidis, Stephanos
    Liu, Dongfang
    Lyne, Paul
    Newcombe, Nicholas
    Pass, Martin
    Read, Jon
    Ready, Shannon
    Rowsell, Sian
    Su, Mei
    Toader, Dorin
    Vasbinder, Melissa
    Yu, Dingwei
    Yu, Yan
    Xue, Yafeng
    Zabludoff, Sonya
    Janetka, James
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (11) : 5130 - 5142
  • [46] Efficacy and Mechanism of Action of Volasertib, a Potent and Selective Inhibitor of Polo-Like Kinases, in Preclinical Models of Acute Myeloid Leukemia
    Rudolph, Dorothea
    Impagnatiello, Maria Antonietta
    Blaukopf, Claudia
    Sommer, Christoph
    Gerlich, Daniel W.
    Roth, Mareike
    Tontsch-Grunt, Ulrike
    Wernitznig, Andreas
    Savarese, Fabio
    Hofmann, Marco H.
    Albrecht, Christoph
    Geiselmann, Lena
    Reschke, Markus
    Garin-Chesa, Pilar
    Zuber, Johannes
    Moll, Juergen
    Adolf, Guenther R.
    Kraut, Norbert
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2015, 352 (03): : 579 - 589
  • [47] A novel, potent inhibitor of Src family kinases with in vivo activity
    Boschelli, Frank
    Golas, Jennifer M.
    Golas, Jonathan
    Lucas, Judy
    Discafani, Carolyn
    Arndt, Kim
    Boschelli, Diane
    CANCER RESEARCH, 2006, 66 (08)
  • [48] Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and HumansS
    Jurva, Ulrik
    Weidolf, Lars
    Sandinge, Ann-Sofie
    Leandersson, Carina
    Ekdahl, Anja
    Li, Xue-Qing
    Antonsson, Thomas
    Sundell, Johan
    Westerlund, Kristina
    Amilon, Carl
    Inghardt, Tord
    Gopaul, V. Sashi
    DRUG METABOLISM AND DISPOSITION, 2023, 51 (04) : 464 - 479
  • [49] Evaluation of fruquintinib, a potent and selective oral VEGFR inhibitor, in combination with targeted therapies or immune checkpoint inhibitors in preclinical tumor models
    Ren, Yongxin
    Sun, Qiaoling
    Long, Jingwen
    Fan, Shiming
    Tang, Renxiang
    Zhang, Wei
    Ge, Xuelei
    Tang, Jianxing
    Wang, Linfang
    Shi, Dongxia
    Chen, Hongbo
    Cheng, Min
    Qing, Weiguo
    Su, Weiguo
    CANCER RESEARCH, 2017, 77
  • [50] Discovery of AZD5363, an orally bioavailable, potent ATP-competitive inhibitor of AKT kinases
    Luke, Richard W.
    Addie, Matthew
    Box, Matthew R.
    Buttar, David
    Crafter, Claire
    Currie, Gordon S.
    Cosulich, Sabina C.
    Davies, Barry
    Dudley, Philippa G.
    Greenwood, Ryan
    Johnson, Paul D.
    Greenwood, Hannah
    Lamont, Gillian M.
    Lane, Clare
    Page, Ken M.
    Pearson, Stuart E.
    Ruston, Linette
    CANCER RESEARCH, 2011, 71