Copper-mediated arylation with arylboronic acids: Facile and modular synthesis of triarylmethanes

被引：23

作者：

Rao, H. Surya Prakash ^{[1
]}

Rao, A. Veera Bhadra ^{[1
]}

机构：

[1] Pondicherry Univ, Dept Chem, Pondicherry 605014, India

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 12卷

关键词：

copper; modular synthesis; triarylmethanes; CROSS-COUPLING REACTIONS; AROMATIC-ALDEHYDES; TRIETHYL ORTHOFORMATE; STRUCTURE ELUCIDATION; REDUCTASE INHIBITORS; ANTIVIRAL ACTIVITIES; BENZYLIC ALCOHOLS; RATIONAL DESIGN; CUPRIC ACETATE; ARYL HALIDES;

D O I：

10.3762/bjoc.12.49

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and modular synthesis of triarylmethanes was achieved in good yield via a two-step sequence in which the final step is the copper(II)-catalyzed arylation of diarylmethanols with arylboronic acids. By using this protocol a variety of symmetrical and unsymmetrical triarylmethanes were synthesized. As an application of the newly developed methodology, we demonstrate a high-yielding synthesis of the triarylmethane intermediate towards an anti-breast-cancer drug candidate.

引用

页码：496 / 504

页数：9

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