Palladium-catalyzed direct C-2 arylation of indoles with potassium aryltrifluoroborate salts

被引：153

作者：

Zhao, Jinlong ^{[1
]}

Zhang, Yuhong ^{[1
]}

Cheng, Kai ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 18期

关键词：

D O I：

10.1021/jo801371w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mild conditions have been developed to achieve Pd(OAc)(2)-catalyzed regioselective cross-coupling between indoles and potassium aryltrifluoroarylborates in the presence of Cu(OAc)(2) in acetic acid at room temperature. A variety of potassium aryltrifluoroborates selectively undergo the direct arylation across indoles and afford 2-aryl indoles in moderate to good yields.

引用

页码：7428 / 7431

页数：4

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