Palladium-Catalyzed Direct Arylation of Polysubstituted Benzofurans

被引：60
|
作者：
Carrer, Amandine [1 ,2 ]
Brinet, Dimitri [1 ,2 ]
Forent, Jean-Claude [1 ,2 ]
Rousselle, Patricia [3 ]
Bertounesque, Emmanuel [1 ,2 ]
机构：
[1] CNRS UMR 176, F-75248 Paris, France
[2] Inst Curie, Ctr Rech, F-75248 Paris, France
[3] CNRS UMR 5086, Inst Biol & Chim Prot, F-69367 Lyon, France
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 03期
关键词：
PROTON-ABSTRACTION MECHANISM; C-H FUNCTIONALIZATION; SOLID-PHASE SYNTHESIS; ARYL BOND FORMATION; EFFICIENT SYNTHESIS; C-2; ARYLATION; ACID; DERIVATIVES; CYCLIZATION; ANNULATION;
D O I：
10.1021/jo202060k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient access to 2-substituted 3-arylbenzofurans through a palladium-catalyzed C3 direct arylation of 2-substituted benzofurans with aryl bromides is described. The scope and limitation of this reaction was studied. The method tolerates a variety of functional groups on the aryl halide and has been successfully extended to polysubstituted benzofurans to obtain the corresponding 3-arylbenzofurans with good to excellent yields.
引用
收藏
页码：1316 / 1327
页数：12
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