Synthetic developments towards PNA-peptide conjugates

被引：30
|
作者：
de Koning, MC [1 ]
van der Marel, GA [1 ]
Overhand, M [1 ]
机构：
[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2003年 / 7卷 / 06期
关键词：
D O I：
10.1016/j.cbpa.2003.10.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Since the discovery of peptide nucleic acids (PNAs) as DNA mimics in the early 1990s, a tremendous effort has been directed to their application as antisense and antigene probes. With the aim of further enhancing their properties, PNAs have been conjugated to a variety of effector molecules. Among these, small peptide fragments, often derived from functional proteins, are able to convey their specific properties to the conjugate.
引用
收藏
页码：734 / 740
页数：7
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