Toward synthetic transcription activators: Recruitment of transcription factors to DNA by a PNA-peptide chimera

被引：33
|
作者：
Liu, B
Han, Y
Corey, DR
Kodadek, T
机构：
[1] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA
[3] Univ Texas, SW Med Ctr, Ctr Biomed Invent, Dallas, TX 75390 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 09期
关键词：
D O I：
10.1021/ja0164226
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A PNA-peptide chimera designed to mimic the biochemical function of transcription activators has been synthesized and characterized. The bis-PNA segment binds specifically to a DNA site while the 20-residue peptide is capable of binding to the transcription factors Gal11 and Gal80. The PNA-peptide chimera thus mimics one of the central functions of a native transcription activator, recruitment of transcription factors to a specific DNA site. Copyright © 2002 American Chemical Society.
引用
收藏
页码：1838 / 1839
页数：2
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