Toward synthetic transcription activators: Recruitment of transcription factors to DNA by a PNA-peptide chimera

被引：33
|
作者：
Liu, B
Han, Y
Corey, DR
Kodadek, T
机构：
[1] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA
[3] Univ Texas, SW Med Ctr, Ctr Biomed Invent, Dallas, TX 75390 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 09期
关键词：
D O I：
10.1021/ja0164226
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A PNA-peptide chimera designed to mimic the biochemical function of transcription activators has been synthesized and characterized. The bis-PNA segment binds specifically to a DNA site while the 20-residue peptide is capable of binding to the transcription factors Gal11 and Gal80. The PNA-peptide chimera thus mimics one of the central functions of a native transcription activator, recruitment of transcription factors to a specific DNA site. Copyright © 2002 American Chemical Society.
引用
收藏
页码：1838 / 1839
页数：2
相关论文
共 50 条
  • [21] Enhancement of TBP binding by activators and general transcription factors
    Nature, 6736 (605-609):
  • [22] BENDING OF DNA BY TRANSCRIPTION FACTORS
    VANDERVLIET, PC
    VERRIJZER, CP
    BIOESSAYS, 1993, 15 (01) : 25 - 32
  • [23] Molecular interactions between nuclear factor κB (NF-κB) transcription factors and a PNA-DNA chimera mimicking NF-κB binding sites
    Romanelli, A
    Pedone, C
    Saviano, M
    Bianchi, N
    Borgatti, M
    Mischiati, C
    Gambari, R
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 2001, 268 (23): : 6066 - 6075
  • [24] Plant synthetic promoters and transcription factors
    Liu, Wusheng
    Stewart, C. Neal, Jr.
    CURRENT OPINION IN BIOTECHNOLOGY, 2016, 37 : 36 - 44
  • [25] Biological activity and delivery of peptide nucleic acids (PNA)-DNA chimeras for transcription factor decoy (TFD) pharmacotherapy
    Gambari, R
    CURRENT MEDICINAL CHEMISTRY, 2004, 11 (10) : 1253 - 1263
  • [26] Synthetic transcription elongation factors license transcription across repressive chromatin
    Erwin, Graham S.
    Grieshop, Matthew P.
    Ali, Asfa
    Qi, Jun
    Lawlor, Matthew
    Kumar, Deepak
    Ahmad, Istaq
    McNally, Anna
    Teider, Natalia
    Worringer, Katie
    Sivasankaran, Rajeev
    Syed, Deeba N.
    Eguchi, Asuka
    Ashraf, Md.
    Jeffery, Justin
    Xu, Mousheng
    Park, Paul M. C.
    Mukhtar, Hasan
    Srivastava, Achal K.
    Faruq, Mohammed
    Bradner, James E.
    Ansari, Aseem Z.
    SCIENCE, 2017, 358 (6370) : 1617 - 1621
  • [27] A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus
    Yu, Zutao
    Ai, Mengting
    Samanta, Soumen K. K.
    Hashiya, Fumitaka
    Taniguchi, Junichi
    Asamitsu, Sefan
    Ikeda, Shuji
    Hashiya, Kaori
    Bando, Toshikazu
    Pandian, Ganesh N. N.
    Isaacs, Lyle
    Sugiyama, Hiroshi
    CHEMICAL COMMUNICATIONS, 2020, 56 (15) : 2296 - 2299
  • [28] PNA-peptide conjugates for regulation of DNA and RNA G-quadruplex structures depending on a particular protease concentration
    Usui, K.
    Kobayashi, K.
    Sugimoto, N.
    JOURNAL OF PEPTIDE SCIENCE, 2010, 16 : 197 - 197
  • [29] Target-specific inhibition of transcription factors by designed, synthetic DNA ligands
    Wilson, W. David
    Paul, Ananya
    Guo, Pu
    Vo, Tam
    Harika, Narinder
    Kumar, Arvind
    Farahat, Abdelbasset
    Liu, Beibei
    Poon, Gregory
    Germann, Markus
    David, Boykin
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
  • [30] A peptide-based synthetic transcription factor selectively activates transcription in a mammalian cell
    Roy, Koushik
    Mazumder, Abhishek
    Ghosh, Piya
    Naiya, Gitashri
    Ghosh, Basusree
    Roy, Siddhartha
    CHEMICAL COMMUNICATIONS, 2018, 54 (13) : 1611 - 1614
12345