Modeled structure of trypanothione reductase of Leishmania infantum

被引：32

作者：

Singh, Bishal K. ^{[1
]}

Sarkar, Nandini ^{[1
]}

Jagannadham, M. V. ^{[2
]}

Dubey, Vikash K. ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Biotechnol, Gauhati 781039, Assam, India

[2] Banaras Hindu Univ, Inst Med Sci, Mol Biol Unit, Varanasi 221005, Uttar Pradesh, India

来源：

BMB REPORTS | 2008年 / 41卷 / 06期

关键词：

drug design; structure-function; reductase activity; homology Modeling;

D O I：

10.5483/BMBRep.2008.41.6.444

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trypanothione reductase is an important target enzyme for structure-based drug design against Leishmania. We used homology modeling to construct a three-dimensional structure of the trypanothione reductase (TR) of Leishmania infantum. The structure shows acceptable Ramachandran statistics and a remarkably different active site from glutathione reductase(GR). Thus, a specific inhibitor against TR can be designed without interfering with host (human) GR activity.

引用

页码：444 / 447

页数：4

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