Modeled structure of trypanothione reductase of Leishmania infantum

被引：32
|
作者：
Singh, Bishal K. [1 ]
Sarkar, Nandini [1 ]
Jagannadham, M. V. [2 ]
Dubey, Vikash K. [1 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Biotechnol, Gauhati 781039, Assam, India
[2] Banaras Hindu Univ, Inst Med Sci, Mol Biol Unit, Varanasi 221005, Uttar Pradesh, India
来源：
BMB REPORTS | 2008年 / 41卷 / 06期
关键词：
drug design; structure-function; reductase activity; homology Modeling;
D O I：
10.5483/BMBRep.2008.41.6.444
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Trypanothione reductase is an important target enzyme for structure-based drug design against Leishmania. We used homology modeling to construct a three-dimensional structure of the trypanothione reductase (TR) of Leishmania infantum. The structure shows acceptable Ramachandran statistics and a remarkably different active site from glutathione reductase(GR). Thus, a specific inhibitor against TR can be designed without interfering with host (human) GR activity.
引用
收藏
页码：444 / 447
页数：4
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