Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues

被引：64
|
作者：
León, R
Marco-Contelles, J
García, AG
Villarroya, M
机构：
[1] CSIC, Inst Quim Organ Gen, Lab Radicales Libres, E-28006 Madrid, Spain
[2] Univ Autonoma Madrid, Fac Med, Dept Farmacol & Terapeut, Inst Teofilo Hernando, E-28029 Madrid, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 04期
关键词：
tacrine analogues; inhibitors; AChE; neuroprotection;
D O I：
10.1016/j.bmc.2004.11.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis and the biological evaluation (acetylcholinesterase inhibition activity and neuroprotection) of the new tacrine analogues 2-14 is described. (C) 2004 Published by Elsevier Ltd.
引用
收藏
页码：1167 / 1175
页数：9
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