Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues

被引：64
|
作者：
León, R
Marco-Contelles, J
García, AG
Villarroya, M
机构：
[1] CSIC, Inst Quim Organ Gen, Lab Radicales Libres, E-28006 Madrid, Spain
[2] Univ Autonoma Madrid, Fac Med, Dept Farmacol & Terapeut, Inst Teofilo Hernando, E-28029 Madrid, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 04期
关键词：
tacrine analogues; inhibitors; AChE; neuroprotection;
D O I：
10.1016/j.bmc.2004.11.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis and the biological evaluation (acetylcholinesterase inhibition activity and neuroprotection) of the new tacrine analogues 2-14 is described. (C) 2004 Published by Elsevier Ltd.
引用
收藏
页码：1167 / 1175
页数：9
相关论文
共 50 条
  • [21] Synthesis and acetylcholinesterase inhibitory activity of fluorinated analogues of huperzine A
    Kaneko, S
    Nakajima, N
    Shikano, M
    Katoh, T
    Terashima, S
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (16) : 1927 - 1930
  • [22] Facile synthesis of novel tacrine analogues
    Hu, Huanan
    Zhang, Anjiang
    Ding, Lisheng
    JOURNAL OF CHEMICAL RESEARCH, 2009, (09) : 562 - 564
  • [23] Novel tacrine derivatives exhibiting improved acetylcholinesterase inhibition: Design, synthesis and biological evaluation
    Reddy, Eeda Koti
    Remya, Chandran
    Mantosh, Kumar
    Sajith, Ayyiliath M.
    Omkumar, R. V.
    Sadasivan, C.
    Anwar, Shaik
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 139 : 367 - 377
  • [24] Tacrine-mefenamic acid hybrids for inhibition of acetylcholinesterase
    Bornstein, Joshua J.
    Eckroat, Todd J.
    Houghton, Jacob L.
    Jones, Christopher K.
    Green, Keith D.
    Garneau-Tsodikova, Sylvie
    MEDCHEMCOMM, 2011, 2 (05) : 406 - 412
  • [25] Synthesis of thiophene analogues of the tacrine series
    Thomae, David
    Kirsch, Gilbert
    Seck, Pierre
    SYNTHESIS-STUTTGART, 2007, (07): : 1027 - 1032
  • [26] Neuroprotective activity and acetylcholinesterase inhibition of five Amaryllidaceae species: A comparative study
    Cortes, Natalie
    Posada-Duque, Rafael Andres
    Alvarez, Rafael
    Alzate, Fernando
    Berkov, Strahil
    Cardona-Gomez, Gloria Patricia
    Osorio, Edison
    LIFE SCIENCES, 2015, 122 : 42 - 50
  • [27] Synthesis of Novel Tacrine Analogs as Acetylcholinesterase Inhibitors
    Mahdavi, Mohammad
    Saeedi, Mina
    Gholamnia, Laleh
    Jeddi, Seyed Amir Behzad
    Sabourian, Reyhaneh
    Shafiee, Abbas
    Foroumadi, Alireza
    Akbarzadeh, Tahmineh
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2017, 54 (01) : 384 - 390
  • [28] Synthesis and Biological Evaluation of New Tacrine Analogues under Microwave Irradiation
    Alshareef, Hossa Fahad
    Mohamed, Heba Abd El Hady
    Salaheldin, Abdellatif Mohamed
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2017, 65 (08) : 732 - 738
  • [29] Synthesis of Fibrauretin Derivatives and Their Inhibition on Acetylcholinesterase Activity
    Xing Zhi-Heng
    Lyu Na
    He Zhong-Mei
    Gao Yu-Gang
    Zhao Yan
    Zhu Hong-Yan
    Yang He
    Zhang Lian-Xue
    CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2018, 46 (05) : 684 - 689
  • [30] Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues
    Zhou, Xiang
    Wang, Xiao-Bing
    Wang, Tao
    Kong, Ling-Yi
    BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (17) : 8011 - 8021
12345