Synthesis and Neuroprotective Activity of Neolamellarin A Analogues

被引：0
|
作者：
Meng Zhang
Ruijuan Yin
Yiran Zhang
Cui Hao
Lijuan Zhang
Tao Jiang
机构：
[1] Affiliated Hospital of Qingdao University,Systems Biology and Medicine Center for Complex Diseases
[2] Ocean University of China,School of Medicine and Pharmacy
[3] Marine Biomedical Research Institute of Qingdao,undefined
来源：
Journal of Ocean University of China | 2018年 / 17卷
关键词：
alkaloids; neolamellarin A; synthesis; PC12 cells; neuroprotective activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Alkaloids are a class of natural products with a wide range of biological activities. Due to the special living environment, the alkaloids from marine sponges have exhibited different biological activities and promising medical application potential. Neolamellarin A is a marine alkaloid possessing bisaryl-pyrrole structural features. Here, the synthesis of 12 different 3,4-bisaryl-N-alkylated permethylated analogues of neolamellarin A and their outstanding neuroprotective activity in PC12 cells are presented and discussed.
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页码：967 / 972
页数：5
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