Effect of the Synadenium carinatum latex lectin (ScLL) on Leishmania (Leishmania) amazonensis infection in murine macrophages

被引：22
|
作者：
Afonso-Cardoso, Sandra R. [1 ]
Silva, Claudio Vieira [1 ]
Ferreira, Marcelo S. [2 ]
Souza, Maria A. [1 ]
机构：
[1] Univ Fed Uberlandia, Inst Ciencias Biomed, BR-38400902 Uberlandia, MG, Brazil
[2] Univ Fed Uberlandia, Fac Med, BR-38400902 Uberlandia, MG, Brazil
来源：
EXPERIMENTAL PARASITOLOGY | 2011年 / 128卷 / 01期
关键词：
Leishmania (Leishmania) amazonensis; Synadenium carinatum; Leishmanicidal activity; Nitric oxide; Lectin; NITRIC-OXIDE PRODUCTION; GALACTOSE-BINDING LECTIN; ANTILEISHMANIAL ACTIVITY; CUTANEOUS LEISHMANIASIS; POSSIBLE INVOLVEMENT; IN-VITRO; FLAVONOIDS; INHIBITION; RESISTANCE; EFFICACY;
D O I：
10.1016/j.exppara.2011.02.006
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Antiparasitic effect of a lectin isolated from Synadenium carinatum latex (ScLL) was evaluated against Leishmania (Leishmania) amazonensis promastigotes/amastigotes. Pretreatment of murine inflammatory peritoneal macrophages with ScLL reduced by 65.5% the association index of macrophages and L. (L) amazonensis promastigotes. Expression of cytokines (IL-12, IL-1 and TNF-alpha) was detected in infected macrophages pretreated with ScLL (10 mu g/mL). ScLL also reduced the growth oft. (L) amazonensis amastigote intracellular forms, showing no in vitro cytotoxic effects in mammalian host cells. ScLL treatment in infected murine inflammatory peritoneal macrophages did not induce nitric oxide production, suggesting that a nitric oxide independent pathway is activated to decrease the number of intracellular Leishmania. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：61 / 67
页数：7
相关论文
共 50 条
  • [41] T-CELL RESPONSE IN MURINE LEISHMANIA-MEXICANA-AMAZONENSIS INFECTION
    CHAN, MMY
    FONG, D
    FASEB JOURNAL, 1992, 6 (04): : A1220 - A1220
  • [42] Effect of Isolated Proteins from Crotalus durissus terrificus Venom on Leishmania (Leishmania) Amazonensis-Infected Macrophages
    Katz, Simone
    Barbieri, Clara Lucia
    Martins Soler, Fernanda Paula
    Soares, Andreimar Martins
    Chavantes, Maria Cristina
    Zamuner, Stella Regina
    PROTEIN AND PEPTIDE LETTERS, 2020, 27 (08): : 718 - 724
  • [43] Leishmania donovani nucleoside hydrolase terminal domains in cross-protective immunotnerapy against Leishmania amazonensis murine infection
    Nico, Dirlei
    Gomes, Daniele Crespo
    Palatnik-de-Sousa, Iam
    Morrot, Alexandre
    Palatnik, Marcos
    Palatnik-de-Sousa, Clarisa Beatriz
    FRONTIERS IN IMMUNOLOGY, 2014, 5 : 1 - 12
  • [44] IL-32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis
    Gomes, Rodrigo Saar
    Teodoro Silva, Muriel Vilela
    dos Santos, Jessica Cristina
    de Lima Silva, Lucas Luiz
    Batista, Aline Carvalho
    Machado, Juliana Reis
    Teixeira, Mauro Martins
    Dorta, Miriam Leandro
    Pelli de Oliveira, Milton Adriano
    Dinarello, Charles A.
    Joosten, Leo A. B.
    Ribeiro-Dias, Fatima
    PARASITES & VECTORS, 2017, 10
  • [45] IL-32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis
    Rodrigo Saar Gomes
    Muriel Vilela Teodoro Silva
    Jéssica Cristina dos Santos
    Lucas Luiz de Lima Silva
    Aline Carvalho Batista
    Juliana Reis Machado
    Mauro Martins Teixeira
    Miriam Leandro Dorta
    Milton Adriano Pelli de Oliveira
    Charles A Dinarello
    Leo A. B. Joosten
    Fátima Ribeiro-Dias
    Parasites & Vectors, 10
  • [46] Effect of testosterone on Leishmania donovani infection of macrophages
    Zhang, HP
    Zhao, JH
    Wang, PG
    Qiao, ZD
    PARASITOLOGY RESEARCH, 2001, 87 (08) : 674 - 676
  • [47] Galectin-3 plays a protective role in Leishmania (Leishmania) amazonensis infection
    Oliveira, Rafael M.
    Teixeira, Thaise L.
    Rodrigues, Cassiano C.
    da Silva, Aline A.
    Borges, Bruna C.
    Brigido, Rebecca T. S.
    Teixeira, Samuel C.
    Dos Santos, Marlus A.
    Servato, Joao Paulo S.
    Santos, Debora de O.
    Silva, Marcelo J. B.
    Goulart, Luiz R.
    da Silva, Claudio, V
    GLYCOBIOLOGY, 2021, 31 (10) : 1378 - 1389
  • [48] Leishmanicidal activity of Himatanthus sucuuba latex against Leishmania amazonensis
    Soares, Deivid C.
    Andrade, Alexandre L. S.
    Delorenzi, Jan C.
    Silva, Jefferson R. A.
    Freire-de-Lima, Leonardo
    Falcao, Camila A. B.
    Pinto, Angelo C.
    Rossi-Bergmann, Bartira
    Saraiva, Elvira M.
    PARASITOLOGY INTERNATIONAL, 2010, 59 (02) : 173 - 177
  • [49] Effect of testosterone on Leishmania donovani infection of macrophages
    Huaping Zhang
    Jiahui Zhao
    Peigang Wang
    Zhongdong Qiao
    Parasitology Research, 2001, 87 : 674 - 676
  • [50] Natural canine infection by Leishmania infantum and Leishmania amazonensis and their implications for disease control
    Sanches, Leticia da Cruz
    de Martini, Cleber Costa
    Nakamura, Alex Akira
    Bodini Santiago, Maria Emilia
    de Lima, Beatriz Dolabela
    Felix de Lima, Valeria Marcal
    REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA, 2016, 25 (04): : 465 - 469
12345