Effect of the Synadenium carinatum latex lectin (ScLL) on Leishmania (Leishmania) amazonensis infection in murine macrophages

被引：22
|
作者：
Afonso-Cardoso, Sandra R. [1 ]
Silva, Claudio Vieira [1 ]
Ferreira, Marcelo S. [2 ]
Souza, Maria A. [1 ]
机构：
[1] Univ Fed Uberlandia, Inst Ciencias Biomed, BR-38400902 Uberlandia, MG, Brazil
[2] Univ Fed Uberlandia, Fac Med, BR-38400902 Uberlandia, MG, Brazil
来源：
EXPERIMENTAL PARASITOLOGY | 2011年 / 128卷 / 01期
关键词：
Leishmania (Leishmania) amazonensis; Synadenium carinatum; Leishmanicidal activity; Nitric oxide; Lectin; NITRIC-OXIDE PRODUCTION; GALACTOSE-BINDING LECTIN; ANTILEISHMANIAL ACTIVITY; CUTANEOUS LEISHMANIASIS; POSSIBLE INVOLVEMENT; IN-VITRO; FLAVONOIDS; INHIBITION; RESISTANCE; EFFICACY;
D O I：
10.1016/j.exppara.2011.02.006
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Antiparasitic effect of a lectin isolated from Synadenium carinatum latex (ScLL) was evaluated against Leishmania (Leishmania) amazonensis promastigotes/amastigotes. Pretreatment of murine inflammatory peritoneal macrophages with ScLL reduced by 65.5% the association index of macrophages and L. (L) amazonensis promastigotes. Expression of cytokines (IL-12, IL-1 and TNF-alpha) was detected in infected macrophages pretreated with ScLL (10 mu g/mL). ScLL also reduced the growth oft. (L) amazonensis amastigote intracellular forms, showing no in vitro cytotoxic effects in mammalian host cells. ScLL treatment in infected murine inflammatory peritoneal macrophages did not induce nitric oxide production, suggesting that a nitric oxide independent pathway is activated to decrease the number of intracellular Leishmania. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：61 / 67
页数：7
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