DEVELOPMENT OF BRAIN-PENETRANT EGFR INHIBITORS FOR CNS MALIGNANCIES

被引:0
|
作者
Tsang, Jonathan [1 ]
Urner, Lorenz [1 ]
Tse, Christopher [1 ]
Baufeld, Lynn [1 ]
Faull, Kym [1 ]
Clark, Peter [1 ]
Cloughesy, Timothy [1 ]
Jung, Michael [1 ]
Nathanson, David [1 ]
机构
[1] Univ Calif Los Angeles, Los Angeles, CA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
DDIS-17
引用
收藏
页码:66 / 66
页数:1
相关论文
共 50 条
  • [1] DEVELOPMENT OF BRAIN-PENETRANT EGFR INHIBITORS FOR GLIOBLASTOMA
    Tsang, Jonathan
    Urner, Lorenz
    Kim, Gyudong
    Chow, Kingsley
    Clark, Peter
    Cloughesy, Timothy
    Jung, Michael
    Nathanson, David
    NEURO-ONCOLOGY, 2018, 20 : 70 - 70
  • [2] Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes
    Bonazzi, Simone
    Gray, Audrey
    Thomsen, Noel M.
    Biag, Jonathan
    Labbe-Giguere, Nancy
    Keaney, Erin P.
    Malik, Hasnain A.
    Sun, Yingchuan
    Nunez, Jill
    Karki, Rajeshri G.
    Knapp, Mark
    Elling, Robert
    Fuller, John
    Pardee, Gwynn
    Craig, Lucas
    Capre, Ketthsy
    Salas, Sarah
    Gorde, Aakruti
    Liang, Guiqing
    Lubicka, Danuta
    McTighe, Stephanie M.
    Goold, Carleton
    Liu, Shanming
    Deng, Lin
    Hong, Jin
    Fekete, Alexander
    Stadelmann, Pascal
    Frieauff, Wilfried
    Elhajouji, Azeddine
    Bauer, Daniel
    Lerchner, Andreas
    Radetich, Branko
    Furet, Pascal
    Piizzi, Grazia
    Burdette, Doug
    Wilson, Christopher J.
    Peukert, Stefan
    Hamann, Lawrence G.
    Murphy, Leon O.
    Curtis, Daniel
    JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (13) : 9095 - 9119
  • [3] Brain-penetrant kinase chemotherapeutics: Learning from CNS space
    Mader, Mary
    Shi, Yuan
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [4] Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors
    Tsang, Jonathan E.
    Urner, Lorenz M.
    Kim, Gyudong
    Chow, Kingsley
    Baufeld, Lynn
    Faull, Kym
    Cloughesy, Timothy F.
    Clark, Peter M.
    Jung, Michael E.
    Nathanson, David A.
    ACS MEDICINAL CHEMISTRY LETTERS, 2020, 11 (10): : 1799 - 1809
  • [5] 18F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma
    Narayanam, Maruthi Kumar
    Tsang, Jonathan E.
    Xu, Shili
    Nathanson, David A.
    Murphy, Jennifer M.
    CHEMICAL SCIENCE, 2023, 14 (47) : 13825 - 13831
  • [6] Discovery of Brain-Penetrant COMT Inhibitors for the Treatment of Cognitive Impairment
    Carr, Gregory
    Li, Cailian
    DePasquale, Michael
    Tian, Qingjun
    Weinberger, Daniel R.
    Barrow, James
    NEUROPSYCHOPHARMACOLOGY, 2016, 41 : S205 - S205
  • [7] From Serendipity to Intention: Development of Brain-Penetrant PARP1-Selective Inhibitors
    Lynce, Filipa
    Lin, Nancy U.
    CLINICAL CANCER RESEARCH, 2024, 30 (07) : 1217 - 1219
  • [8] Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore
    Tanaka, Yuta
    Seto, Masaki
    Kakegawa, Keiko
    Takami, Kazuaki
    Kikuchi, Fumiaki
    Yamamoto, Takeshi
    Nakamura, Minoru
    Daini, Masaki
    Murakami, Masataka
    Ohashi, Tomohiro
    Kasahara, Takahito
    Wang, Junsi
    Ikeda, Zenichi
    Wada, Yasufumi
    Puenner, Florian
    Fujii, Takahiro
    Inazuka, Masakazu
    Sato, Sho
    Suzaki, Tomohiko
    Oak, Jeong-Ho
    Takai, Yuichi
    Kohara, Hiroshi
    Kimoto, Kouya
    Oki, Hideyuki
    Mikami, Satoshi
    Sasaki, Minoru
    Tanaka, Yuta
    JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (05) : 4270 - 4290
  • [9] The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors
    Graham, Thomas H.
    Shen, Hong C.
    Liu, Wensheng
    Xiong, Yusheng
    Verras, Andreas
    Bleasby, Kelly
    Bhatt, Urmi R.
    Chabin, Renee M.
    Chen, Dunlu
    Chen, Qing
    Garcia-Calvo, Margarita
    Geissler, Wayne M.
    He, Huaibing
    Lassman, Michael E.
    Shen, Zhu
    Tong, Xinchun
    Tung, Elaine C.
    Xie, Dan
    Xu, Suoyu
    Colletti, Steven L.
    Tata, James R.
    Hale, Jeffrey J.
    Pinto, Shirly
    Shen, Dong-Ming
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (01) : 658 - 665
  • [10] Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors
    Shen, Hong C.
    Ding, Fa-Xiang
    Jiang, Jinlong
    Verras, Andreas
    Chabin, Renee M.
    Xu, Suoyu
    Tong, Xinchun
    Chen, Qing
    Xie, Dan
    Lassman, Mike E.
    Bhatt, Urmi R.
    Garcia-Calvo, Margarita M.
    Geissler, Wayne
    Shen, Zhu
    Murphy, Beth Ann
    Gorski, Judith N.
    Wiltsie, Judyann
    SinhaRoy, Ranabir
    Hale, Jeffrey J.
    Pinto, Shirly
    Shen, Dong-Ming
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (04) : 1550 - 1556