Identification of a Novel CRF01_AE/CRF07_BC Recombinant Form in Men Who Have Sex with Men in Sichuan, China

被引：1

作者：

Wang, Yan ^{[1
]}

Wei, Huamian ^{[2
,3
,4
]}

Xu, Weisi ^{[1
]}

Yin, Qianqian ^{[1
]}

Feng, Yi ^{[1
]}

Liang, Shu ^{[5
]}

Shao, Yiming ^{[1
]}

Ma, Liying ^{[1
]}

机构：

[1] Chinese Ctr Dis Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Di, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China

[2] Chinese Acad Med Sci, Pathogens Inst Pathogen Biol, MOH Key Lab Syst Biol, Beijing, Peoples R China

[3] Chinese Acad Med Sci, AIDS Res Ctr, Beijing, Peoples R China

[4] Peking Union Med Coll, Beijing, Peoples R China

[5] Sichuan Ctr Dis Control & Prevent, Chengdu, Peoples R China

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2016年 / 32卷 / 07期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1089/aid.2015.0276

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A novel second-generation CCR5-tropic HIV-1 recombinant virus (XC2014EU09) was identified here, which was isolated from a HIV-positive man who had sex with men (MSM) in Sichuan, China. Phylogenic analyses showed that XC2014EU09 was composed of two well-established circulating recombinant forms (CRF01_AE and CRF07_BC). Different from the other four reported CRF01_AE/CRF07_BC recombinant forms, three recombinant breakpoints of XC2014EU09 with four fragments were observed in the vpr, env, and nef genes, respectively, as follows: I-CRF01_AE (636-5,843 nt), IICRF07_BC (5,844-8,393 nt), IIICRF01_AE (8,394-9,119 nt), and IVCRF07_BC (9,120-9,600 nt). The emergence of CRF01_AE/CRF07_BC recombinant strain indicates the increasing complexity of the HIV-1 epidemic among the MSM group in China.

引用

页码：718 / 721

页数：4

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