Four Closely Related HIV-1 CRF01_AE/CRF07_BC Recombinant Forms Identified in East China

被引：2
|
作者：
Li, Fan [1 ]
Li, Yuxueyun [1 ]
Feng, Yi [1 ]
Hu, Jing [1 ]
Ruan, Yuhua [1 ]
Xing, Hui [1 ]
Shao, Yiming [1 ,2 ,3 ]
机构：
[1] Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China
[2] Peking Univ, Ctr Infect Dis, Beijing, Peoples R China
[3] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2017年 / 33卷 / 07期
基金：
中国国家自然科学基金;
关键词：
HIV-1; recombinant form; NFLG;
D O I：
10.1089/aid.2017.0049
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Five near full-length genomes of novel second-generation HIV-1 recombinant virus (JS150021, JS150029, JS150129, JS150132, and AH150183) were identified from five HIV-positive people in Jiangsu and Anhui province, east China. Phylogenic analyses showed that these five sequences are all composed of two well-established circulating recombinant forms (CRFs) CRF07_BC and CRF01_AE, grouped into four new discovered recombinant forms, which show several very similar but not identical recombinant breakpoints. The four recombinant forms are also identified to be a sort of family or related viruses, seems to be the results of different recombination events. The emergence of a serious new closely related CRF07_BC/CRF01_AE recombinant strain indicates the increasing complexity of sexual transmission of the HIV-1 epidemic in China.
引用
收藏
页码：740 / 744
页数：5
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