Omicron Breakthrough Infection After Heterologous Prime-Boost Vaccination Induces a Vigorous Antibody Response

被引：4

作者：

Varese, Augusto ^{[1
,2
]}

Mazzitelli, Bianca ^{[1
,2
]}

Erra Diaz, Fernando ^{[1
,2
]}

Kjolhede, Maria Victoria ^{[1
,2
]}

Ojeda, Diego ^{[3
]}

Vellicce, Alejandra ^{[4
]}

Arto, Penelope ^{[4
]}

Cicero, Carla ^{[4
]}

Pascowski, Maria ^{[5
]}

Figueras, Laura ^{[6
]}

Broese, Barbara ^{[6
]}

Davila, Rosa ^{[7
]}

Zarlenga, Rocio ^{[1
,2
]}

Rivelli, Federico ^{[1
,2
]}

Verruno, Camila ^{[1
,2
]}

Silenzi, Valeria ^{[1
,2
]}

Beltran, Ivana ^{[1
,2
]}

Gamarnik, Andrea ^{[3
]}

Ceballos, Ana ^{[1
,2
]}

Zala, Carlos ^{[6
]}

Badolati, Adelina ^{[5
]}

Geffner, Jorge ^{[1
,2
]}

机构：

[1] Univ Buenos Aires, Fac Med, Inst Invest Biomed Retrovirus, Paraguay 2155 Piso 11,C1121 ABG, Buenos Aires, DF, Argentina

[2] Consejo Nacl Invest Cient & Tecn, SIDA, Buenos Aires, DF, Argentina

[3] Consejo Nacl Invest Cient & Tecn, Fundacien Inst Leloir, Buenos Aires, DF, Argentina

[4] Hosp Clin Jose San Martin, Buenos Aires, DF, Argentina

[5] Hosp Alejandro Posadas, Buenos Aires, DF, Argentina

[6] Hosp Cent San Isidro Melchor A Posse, Buenos Aires, DF, Argentina

[7] Hosp Villa Mercedes Juan Domingo Peron, San Luis, Argentina

来源：

JOURNAL OF INFECTIOUS DISEASES | 2022年 / 226卷 / 10期

关键词：

COVID-19; SARS-CoV-2; Omicron; neutralizing antibodies;

D O I：

10.1093/infdis/jiac250

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is usually asymptomatic or mild and appears to be poorly immunogenic at least in unvaccinated individuals. Here, we found that health care workers vaccinated with 2 doses of Sputnik V and a booster dose of ChAdOx1 mount a vigorous neutralizing-antibody response after Omicron breakthrough infection. Breakthrough infections with SARS-CoV-2 Omicron are seen with increasing frequency. We found that Omicron breakthrough infection after heterologous vaccination with 2 doses of Sputnik V and a booster dose of ChAdOx1 induces a strong neutralizing response against Omicron.

引用

页码：1717 / 1720

页数：4

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