Omicron Breakthrough Infection After Heterologous Prime-Boost Vaccination Induces a Vigorous Antibody Response

被引：4

作者：

Varese, Augusto ^{[1
,2
]}

Mazzitelli, Bianca ^{[1
,2
]}

Erra Diaz, Fernando ^{[1
,2
]}

Kjolhede, Maria Victoria ^{[1
,2
]}

Ojeda, Diego ^{[3
]}

Vellicce, Alejandra ^{[4
]}

Arto, Penelope ^{[4
]}

Cicero, Carla ^{[4
]}

Pascowski, Maria ^{[5
]}

Figueras, Laura ^{[6
]}

Broese, Barbara ^{[6
]}

Davila, Rosa ^{[7
]}

Zarlenga, Rocio ^{[1
,2
]}

Rivelli, Federico ^{[1
,2
]}

Verruno, Camila ^{[1
,2
]}

Silenzi, Valeria ^{[1
,2
]}

Beltran, Ivana ^{[1
,2
]}

Gamarnik, Andrea ^{[3
]}

Ceballos, Ana ^{[1
,2
]}

Zala, Carlos ^{[6
]}

Badolati, Adelina ^{[5
]}

Geffner, Jorge ^{[1
,2
]}

机构：

[1] Univ Buenos Aires, Fac Med, Inst Invest Biomed Retrovirus, Paraguay 2155 Piso 11,C1121 ABG, Buenos Aires, DF, Argentina

[2] Consejo Nacl Invest Cient & Tecn, SIDA, Buenos Aires, DF, Argentina

[3] Consejo Nacl Invest Cient & Tecn, Fundacien Inst Leloir, Buenos Aires, DF, Argentina

[4] Hosp Clin Jose San Martin, Buenos Aires, DF, Argentina

[5] Hosp Alejandro Posadas, Buenos Aires, DF, Argentina

[6] Hosp Cent San Isidro Melchor A Posse, Buenos Aires, DF, Argentina

[7] Hosp Villa Mercedes Juan Domingo Peron, San Luis, Argentina

来源：

JOURNAL OF INFECTIOUS DISEASES | 2022年 / 226卷 / 10期

关键词：

COVID-19; SARS-CoV-2; Omicron; neutralizing antibodies;

D O I：

10.1093/infdis/jiac250

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is usually asymptomatic or mild and appears to be poorly immunogenic at least in unvaccinated individuals. Here, we found that health care workers vaccinated with 2 doses of Sputnik V and a booster dose of ChAdOx1 mount a vigorous neutralizing-antibody response after Omicron breakthrough infection. Breakthrough infections with SARS-CoV-2 Omicron are seen with increasing frequency. We found that Omicron breakthrough infection after heterologous vaccination with 2 doses of Sputnik V and a booster dose of ChAdOx1 induces a strong neutralizing response against Omicron.

引用

页码：1717 / 1720

页数：4

共 50 条

[31] Homologous and Heterologous Prime-Boost Vaccination: Impact on Clinical Severity of SARS-CoV-2 Omicron Infection among Hospitalized COVID-19 Patients in Belgium
Meurisse, Marjan
Catteau, Lucy
van Loenhout, Joris A. F.
Braeye, Toon
De Mot, Laurane
Serrien, Ben
Blot, Koen
Cauet, Emilie
Van Oyen, Herman
Cuypers, Lize
Robert, Annie
Van Goethem, Nina
VACCINES, 2023, 11 (02)
[32] Effect of homologous and heterologous prime-boost on the immune response to recombinant plague antigens
Glynn, A
Freytag, LC
Clements, JD
VACCINE, 2005, 23 (16) : 1957 - 1965
[33] Heterologous prime-boost vaccination based on Polymorphic protein D protects against intravaginal Chlamydia trachomatis infection in mice
Romina Cecilia Russi
Diego Del Balzo
Agustín Luján
Ivana Gabriela Reidel
María Inés García
Carolina Veaute
María Teresa Damiani
Scientific Reports, 12
[34] Heterologous prime-boost vaccination based on Polymorphic protein D protects against intravaginal Chlamydia trachomatis infection in mice
Cecilia Russi, Romina
Del Balzo, Diego
Lujan, Agustin
Gabriela Reidel, Ivana
Ines Garcia, Maria
Veaute, Carolina
Teresa Damiani, Maria
SCIENTIFIC REPORTS, 2022, 12 (01)
[35] Jordanians' willingness to receive heterologous prime-boost COVID-19 vaccination and vaccine boosters
Rababa'h, A. M.
Abedalqader, N. N.
Ababneh, M.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2021, 25 (23) : 7516 - 7525
[36] To mix or not to mix? A rapid systematic review of heterologous prime-boost covid-19 vaccination
Chiu, Nan-Chang
Chi, Hsin
Tu, Yu-Kang
Huang, Ya-Ning
Tai, Yu-Lin
Weng, Shun-Long
Chang, Lung
Huang, Daniel Tsung-Ning
Huang, Fu-Yuan
Lin, Chien-Yu
EXPERT REVIEW OF VACCINES, 2021, 20 (10) : 1211 - 1220
[37] Heterologous prime-boost vaccination programs against Newcastle disease virus genotype VII in chickens
Sedeik, M. E.
Awad, A. M.
El-Shall, N. A.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 2022, 87
[38] Intravenous heterologous prime-boost vaccination activates innate and adaptive immunity to promote tumor regression
Ramirez-Valdez, Ramiro A.
Baharom, Faezzah
Khalilnezhad, Ahad
Fussell, Sloane C.
Hermans, Dalton J.
Schrager, Alexander M.
Tobin, Kennedy K. S.
Lynn, Geoffrey M.
Khalilnezhad, Shabnam
Ginhoux, Florent
Van den Eynde, Benoit J.
Leung, Carol Sze Ki
Ishizuka, Andrew S.
Seder, Robert A.
CELL REPORTS, 2023, 42 (06):
[39] Evaluation of Antibody Response to Heterologous Prime-Boost Vaccination with ChAdOx1 nCoV-19 and BNT162b2: An Observational Study
Firinu, Davide
Perra, Andrea
Campagna, Marcello
Littera, Roberto
Meloni, Federico
Sedda, Francesca
Conti, Maria
Costanzo, Giulia
Erbi, Monica
Usai, Gianmario
Locci, Carlotta
Carta, Mauro Giovanni
Cappai, Riccardo
Orru, Germano
Del Giacco, Stefano
Coghe, Ferdinando
Chessa, Luchino
VACCINES, 2021, 9 (12)
[40] Comments on "Serological response and safety of heterologous ChAdOx1-nCoV-19/ mRNA-1273 prime-boost vaccination"
Mungmunpuntipantip, Rujittika
Wiwanitkit, Viroj
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2023, 122 : 82 - 82

← 1 2 3 4 5 →