Two-stage enzyme mediated drug release from LMWG hydrogels

被引:119
|
作者
van Bommel, KJC
Stuart, MCA
Feringa, BL
van Esch, J
机构
[1] Biomade Technol Fdn, NL-9747 AG Groningen, Netherlands
[2] Univ Groningen, Stratingh Inst, Dept Organ & Mol Inorgan Chem, NL-9747 AG Groningen, Netherlands
关键词
D O I
10.1039/b507157g
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An enzymatically cleavable low molecular weight gelator-(model) drug conjugate system can be employed to effect a two-step enzyme mediated drug release, demonstrating the potential of LMWG systems for the development of drug delivery devices.
引用
收藏
页码:2917 / 2920
页数:4
相关论文
共 50 条
  • [41] Two-Stage Countercurrent Enzyme-Assisted Aqueous Extraction Processing of Oil and Protein from Soybeans
    de Moura, Juliana Maria Leite Nobrega
    Johnson, Lawrence A.
    JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 2009, 86 (03) : 283 - 289
  • [42] Release of gentamicin and vancomycin from temporary human hip spacers in two-stage revision of infected arthroplasty
    Minelli, EB
    Benini, A
    Magnan, B
    Bartolozzi, P
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 53 (02) : 329 - 334
  • [43] TWO-STAGE MODEL-FREE TESTS OF SYNERGY IN DRUG COMBINATIONS
    Kelly, Colleen
    Feng, Ping
    Kawashima, Toana
    Wilmes, Anja
    Miller, John
    JOURNAL OF BIOPHARMACEUTICAL STATISTICS, 2012, 22 (01) : 54 - 71
  • [44] A two-stage design for drug screening trials based on continuous endpoints
    Tsou, Hslao-Hui
    Hsiao, Chin-Fu
    Chow, Shein-Chung
    Liu, Jen-pei
    DRUG INFORMATION JOURNAL, 2008, 42 (03): : 253 - 262
  • [45] A Two-Stage Design for Drug Screening Trials Based on Continuous Endpoints
    Hsiao-Hui Tsou
    Chin-Fu Hsiao
    Shein-Chung Chow
    Jen-pei Liu
    Drug information journal : DIJ / Drug Information Association, 2008, 42 (3): : 253 - 262
  • [46] Two-stage Energy Release Process of a Confined Flare with Double HXR Peaks
    Ning, Hao
    Chen, Yao
    Wu, Zhao
    Su, Yang
    Tian, Hui
    Li, Gang
    Du, Guohui
    Song, Hongqiang
    ASTROPHYSICAL JOURNAL, 2018, 854 (02):
  • [47] Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum
    Chen, Yun
    Li, Qian
    Wu, Qingsheng
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2014, 9 : 3175 - 3182
  • [48] A two-stage hybrid flow shop problem with dedicated machine and release date
    Nabli, Zouhour
    Khalfallah, Soulef
    Korbaa, Ouajdi
    KNOWLEDGE-BASED AND INTELLIGENT INFORMATION & ENGINEERING SYSTEMS (KES-2018), 2018, 126 : 214 - 223
  • [49] Interaction of lipoplexes with anionic lipids resulting in DNA release is a two-stage process
    Caracciolo, Giulio
    Pozzi, Daniela
    Amenitsch, Heinz
    Caminiti, Ruggero
    LANGMUIR, 2007, 23 (17) : 8713 - 8717
  • [50] Nanoparticle-loaded hydrogels as a pathway for enzyme-triggered drug release in ophthalmic applications
    Ahlen, Michelle
    Tummala, Gopi Krishna
    Mihranyan, Albert
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 536 (01) : 73 - 81