Multidrug resistance reversal activity of key ningalin analogues

被引：52
|
作者：
Soenen, DR
Hwang, I
Hedrick, MP
Boger, DL
机构：
[1] Scripps Res Inst, La Jolla, CA 92037 USA
[2] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 10期
关键词：
D O I：
10.1016/S0960-894X(03)00294-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Key analogue derivatives of the ningalins, potent multidrug resistance (MDR) reversal compounds, were examined resulting in the discovery of a potent MDR reversal agent that hypersensitizes P-gp resistant tumor cell lines to front-line conventional therapeutic agents. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1777 / 1781
页数：5
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