Multidrug resistance reversal activity of key ningalin analogues

被引：52
|
作者：
Soenen, DR
Hwang, I
Hedrick, MP
Boger, DL
机构：
[1] Scripps Res Inst, La Jolla, CA 92037 USA
[2] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 10期
关键词：
D O I：
10.1016/S0960-894X(03)00294-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Key analogue derivatives of the ningalins, potent multidrug resistance (MDR) reversal compounds, were examined resulting in the discovery of a potent MDR reversal agent that hypersensitizes P-gp resistant tumor cell lines to front-line conventional therapeutic agents. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1777 / 1781
页数：5
相关论文
共 50 条
  • [21] Reversal of multidrug resistance in hematological malignancies
    Vossebeld, PJM
    Sonneveld, P
    BLOOD REVIEWS, 1999, 13 (02) : 67 - 78
  • [22] Reversal of multidrug resistance by amitriptyline in vitro
    Varga, A
    Nugel, H
    Baehr, R
    Marx, U
    Hever, A
    Nacsa, J
    Ocsovszky, I
    Molnar, J
    ANTICANCER RESEARCH, 1996, 16 (01) : 209 - 211
  • [23] Reversal of multidrug resistance of tumor cells
    Szabó, D
    Keyzer, H
    Kaiser, HE
    Molnár, J
    ANTICANCER RESEARCH, 2000, 20 (6B) : 4261 - 4274
  • [24] Multidrug resistance in leukemias and its reversal
    Malayeri, R
    Filipits, M
    Suchomel, RW
    Zochbauer, S
    Lechner, K
    Pirker, R
    LEUKEMIA & LYMPHOMA, 1996, 23 (5-6) : 451 - 458
  • [25] CARBOXYLESTERASES AND THE REVERSAL OF THE MULTIDRUG-RESISTANCE
    MARKOVIC, OT
    MARKOVIC, NS
    MARKOVIC, SN
    CLINICAL RESEARCH, 1994, 42 (02): : A127 - A127
  • [26] <it>In vitro</it> Reversal of Multidrug Resistance in Cancer
    Holcomb-Webb, Kasi
    Gard, Gabrielle
    Vogel, Pia
    Wise, John
    FASEB JOURNAL, 2020, 34
  • [27] Reversal of multidrug resistance by tacrolimus hydrate
    Wu, JH
    Furusawa, S
    Nakano, S
    Takahashi, M
    Chiba, H
    Takayanagi, M
    Takayanagi, Y
    Sasaki, K
    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, 1996, 18 (10): : 651 - 658
  • [28] Reversal of anticancer multidrug resistance by the ardeemins
    Chou, TC
    Depew, KM
    Zheng, YH
    Safer, ML
    Chan, D
    Helfrich, B
    Zatorska, D
    Zatorski, A
    Bornmann, W
    Danishefsky, SJ
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) : 8369 - 8374
  • [29] Novel multidrug resistance reversal agents
    Berger, D
    Citarella, R
    Dutia, M
    Greenberger, L
    Hallett, W
    Paul, R
    Powell, D
    JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (12) : 2145 - 2161
  • [30] REVERSAL OF MULTIDRUG RESISTANCE BY LIPOPHILIC DRUGS
    HOFSLI, E
    NISSENMEYER, J
    CANCER RESEARCH, 1990, 50 (13) : 3997 - 4002
12345