+276G>T Single Nucleotide Polymorphism in the Adiponectine (APM1) Gene in Donors from the Kharkiv Population

被引：0
|
作者：
Atramentova, L. A. [1 ]
Poltorak, V. V. [1 ]
Tyzhnenko, T. V. [1 ]
Gorshunskaya, M. Yu. [2 ]
Pochernyaev, A. R. [1 ]
机构：
[1] Ukrainian Acad Sci, Danilevskii Inst Problems Endocrine Pathol, Kharkov, Ukraine
[2] Kharkiv Med Acad Postgrad Educ, Kharkov, Ukraine
来源：
CYTOLOGY AND GENETICS | 2010年 / 44卷 / 06期
关键词：
INSULIN-RESISTANCE SYNDROME; IMPAIRED GLUCOSE-TOLERANCE; ENCODING ADIPONECTIN; METABOLIC SYNDROME; PROXIMAL PROMOTER; ASSOCIATION; RISK; CAUCASIANS; OBESITY; FAMILY;
D O I：
10.3103/S009545271006006X
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
+276G > T polymorphism in the adiponectine gene (APM1) was studied in 103 samples obtained from donors in the Kharkiv population (men/women: 64/38; 70 Ukrainian, 33 Russian). The T- and G-allele frequencies did not significantly differ between either men and women or between Russians and Ukrainians and comprised p(T) = 0.55 and p(G) = 0.45 in the general group. The genotype distribution deviated from the Hardy-Weinberg equilibrium: the heterozygote frequency was 1.55 times higher compared to the selectively neutral value, while the TT- and GG- homozygote frequencies were 0.55 and 0.33 of the equilibrium value, respectively.
引用
收藏
页码：361 / 364
页数：4
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