+276G>T Single Nucleotide Polymorphism in the Adiponectine (APM1) Gene in Donors from the Kharkiv Population

被引：0
|
作者：
Atramentova, L. A. [1 ]
Poltorak, V. V. [1 ]
Tyzhnenko, T. V. [1 ]
Gorshunskaya, M. Yu. [2 ]
Pochernyaev, A. R. [1 ]
机构：
[1] Ukrainian Acad Sci, Danilevskii Inst Problems Endocrine Pathol, Kharkov, Ukraine
[2] Kharkiv Med Acad Postgrad Educ, Kharkov, Ukraine
来源：
CYTOLOGY AND GENETICS | 2010年 / 44卷 / 06期
关键词：
INSULIN-RESISTANCE SYNDROME; IMPAIRED GLUCOSE-TOLERANCE; ENCODING ADIPONECTIN; METABOLIC SYNDROME; PROXIMAL PROMOTER; ASSOCIATION; RISK; CAUCASIANS; OBESITY; FAMILY;
D O I：
10.3103/S009545271006006X
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
+276G > T polymorphism in the adiponectine gene (APM1) was studied in 103 samples obtained from donors in the Kharkiv population (men/women: 64/38; 70 Ukrainian, 33 Russian). The T- and G-allele frequencies did not significantly differ between either men and women or between Russians and Ukrainians and comprised p(T) = 0.55 and p(G) = 0.45 in the general group. The genotype distribution deviated from the Hardy-Weinberg equilibrium: the heterozygote frequency was 1.55 times higher compared to the selectively neutral value, while the TT- and GG- homozygote frequencies were 0.55 and 0.33 of the equilibrium value, respectively.
引用
收藏
页码：361 / 364
页数：4
相关论文
共 50 条
  • [1] +276G>T single nucleotide polymorphism in the adiponectine (APM1) gene in donors from the Kharkiv population
    L. A. Atramentova
    V. V. Poltorak
    T. V. Tyzhnenko
    M. Yu. Gorshunskaya
    A. R. Pochernyaev
    Cytology and Genetics, 2010, 44 : 361 - 364
  • [2] Association of 276G>T adiponectin gene polymorphism to plasma adiponectin and albuminuria in type 2 diabetic patients
    Kacso, Ina Maria
    Trifa, Adrian Pavel
    Popp, Radu Anghel
    Kacso, Gabriel
    INTERNATIONAL UROLOGY AND NEPHROLOGY, 2012, 44 (06) : 1771 - 1777
  • [3] The+276 polymorphism of the Apm1 gene and plasma adiponectin concentration and cardiovascular risk in diabetic men
    Qi, L
    Li, T
    Rimm, E
    Zhang, CL
    Rifai, N
    Hunter, D
    Doria, A
    Hu, FB
    CIRCULATION, 2005, 111 (14) : E217 - E217
  • [4] The+276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic men
    Qi, L
    Li, T
    Rimm, E
    Zhang, CL
    Rifai, N
    Hunter, D
    Doria, A
    Hu, FB
    DIABETES, 2005, 54 (05) : 1607 - 1610
  • [5] RELATIONSHIP BETWEEN THE ADIPONECTIN (APM1) 276G/T VARIANT AND METABOLIC DISTURBANCES IN A SCHIZOPHRENIA POPULATION RECEIVING ANTIPSYCHOTICS
    Ellingrod, Vicki
    Meden, M.
    Grove, T. B.
    Taylor, S. F.
    Moline, J.
    Miller, D. D.
    Holman, T. L.
    Kerr, J.
    SCHIZOPHRENIA BULLETIN, 2009, 35 : 31 - 31
  • [6] Identification of a Regulatory Single Nucleotide Polymorphism in the Adiponectin (APM1) Gene Associated with Type 2 Diabetes in Han Nationality
    Yang, Min
    Qiu, Chang-Chun
    Chen, Wei
    Xu, Ling-Ling
    Yu, Miao
    Xiang, Hong-Ding
    BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2008, 21 (06) : 454 - 459
  • [7] Identification of a Regulatory Single Nucleotide Polymorphism in the Adiponectin (APM1) Gene Associated with Type 2 Diabetes in Han Nationality
    MIN YANG
    +National Laboratory of Medical Molecular Biology
    Biomedical and Environmental Sciences, 2008, 21 (06) : 454 - 459
  • [8] +276 G/T single nucleotide polymorphism of the adiponectin gene is associated with the susceptibility to biliary atresia
    Wanvisa Udomsinprasert
    Tewin Tencomnao
    Sittisak Honsawek
    Wilai Anomasiri
    Paisarn Vejchapipat
    Voranush Chongsrisawat
    Yong Poovorawan
    World Journal of Pediatrics, 2012, 8 : 328 - 334
  • [9] +276 G/T single nucleotide polymorphism of the adiponectin gene is associated with the susceptibility to biliary atresia
    Udomsinprasert, Wanvisa
    Tencomnao, Tewin
    Honsawek, Sittisak
    Anomasiri, Wilai
    Vejchapipat, Paisarn
    Chongsrisawat, Voranush
    Poovorawan, Yong
    WORLD JOURNAL OF PEDIATRICS, 2012, 8 (04) : 328 - 334
  • [10] Associations between single-nucleotide polymorphisms (+45T>G,+276G>T,-11377C>G,-11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis
    Han, L. Y.
    Wu, Q. H.
    Jiao, M. L.
    Hao, Y. H.
    Liang, L. B.
    Gao, L. J.
    Legge, D. G.
    Quan, H.
    Zhao, M. M.
    Ning, N.
    Kang, Z.
    Sun, H.
    DIABETOLOGIA, 2011, 54 (09) : 2303 - 2314
12345