Recent advances in cloning herpesviral genomes as infectious bacterial artificial chromosomes

被引:7
|
作者
Zhou, Fuchun
Gao, Shou-Jiang [1 ]
机构
[1] Univ Texas Hlth Sci Ctr San Antonio, Greehey Childrens Canc Res Inst, Tumor Virol Program, San Antonio, TX 78229 USA
关键词
herpesvirus; bacteria artificial chromosome; molecular cloning; reverse genetics; mutagenesis; VARICELLA-ZOSTER-VIRUS; TEMPERATURE-SENSITIVE MUTANTS; EPSTEIN-BARR-VIRUS; PHOSPHONOACETIC ACID-RESISTANT; COSMID-BASED SYSTEM; ESCHERICHIA-COLI; SIMPLEX-VIRUS; HUMAN CYTOMEGALOVIRUS; IN-VITRO; BACTERIOPHAGE-LAMBDA;
D O I
10.4161/cc.10.3.14708
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Herpesviruses are common but important pathogens in humans and animals. These viruses have large complex genomes encoding genes with diverse functions in different phases of their life cycle and associated diseases. In the last decade, genomes of herpesviruses cloned as infectious bacterial artificial chromosomes (BACs) have become powerful tools for delineating the functions of viral genes and understanding the pathogenesis of their associated diseases. Here we review the history of herpesviral genetics and recent advances in methods for cloning herpesviral genomes as infectious BACs.
引用
收藏
页码:434 / 440
页数:7
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