Structure-based design of HIV protease inhibitors: Sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors

被引：89
|
作者：
Thaisrivongs, S
Skulnick, HI
Turner, SR
Strohbach, JW
Tommasi, RA
Johnson, PD
Aristoff, PA
Judge, TM
Gammill, RB
Morris, JK
Romines, KR
Chrusciel, RA
Hinshaw, RR
Chong, KT
Tarpley, WG
Poppe, SM
Slade, DE
Lynn, JC
Horng, MM
Tomich, PK
Seest, EP
Dolak, LA
Howe, WJ
Howard, GM
Schwende, FJ
Toth, LN
Padbury, GE
Wilson, GJ
Shiou, LH
Zipp, GL
Wilkinson, KF
Rush, BD
Ruwart, MJ
Koeplinger, KA
Zhao, ZY
Cole, S
Zaya, RM
Kakuk, TJ
Janakiraman, MN
Watenpaugh, KD
机构：
[1] SAMC, Pharmacia and Upjohn, Inc., Kalamazoo
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 22期
关键词：
D O I：
10.1021/jm960541s
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：4349 / 4353
页数：5
相关论文
共 50 条
  • [31] Structure-based design of novel conformationally restricted HIV protease inhibitors
    Rao, B.G.
    Baker, C.T.
    Court, J.T.
    Deininger, D.D.
    Griffith, J.P.
    Kim, E.E.
    Kim, J.L.
    Li, B.
    Pazhanisamy, S.
    Salituro, F.G.
    Schairer, W.C.
    Tung, R.D.
    ACS Symposium Series, 719 : 185 - 197
  • [32] STRUCTURE-BASED DESIGN OF SYMMETRICAL INHIBITORS OF HIV-1 PROTEASE
    ERICKSON, J
    KEMPF, D
    ARCHIVES OF VIROLOGY, 1994, : 19 - 29
  • [33] Asymmetric syntheses and absolute stereochemistry of 5,6-dihydro-alpha-pyrones, a new class of potent HIV protease inhibitors
    Judge, TM
    Phillips, G
    Morris, JK
    Lovasz, KD
    Romines, KR
    Luke, GP
    Tulinsky, J
    Tustin, JM
    Chrusciel, RA
    Dolak, LA
    Mizsak, SA
    Watt, W
    Morris, J
    VanderVelde, SL
    Strohbach, JW
    Gammill, RB
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (15) : 3627 - 3628
  • [34] ITERATIVE STRUCTURE-BASED DESIGN OF POTENT, SYMMETRY BASED HIV PROTEASE INHIBITORS
    RANDAD, RS
    LUBKOWSKA, L
    SILVA, A
    BHAT, TN
    GULNIK, S
    YU, B
    ERICKSON, JW
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 209 : 112 - MEDI
  • [35] Design and synthesis of non-peptidic inhibitors for the Syk C-terminal SH2 domain based on structure-based in-silico screening
    Niimi, T
    Orita, M
    Okazawa-Igarashi, M
    Sakashita, H
    Kikuchi, K
    Ball, E
    Ichikawa, A
    Yamagiwa, Y
    Sakamoto, S
    Tanaka, A
    Tsukamoto, S
    Fujita, S
    Tatsuta, K
    Maeda, Y
    Chikauchi, K
    JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (26) : 4737 - 4740
  • [36] 5,6-DIHYDRO-2H-PYRAN-2-ONES AS NOVEL HIV PROTEASE INHIBITORS
    HAGEN, SE
    DOMAGALA, JM
    ELLSWORTH, EL
    FERGUSON, D
    LUNNEY, EA
    TAIT, BD
    TUIT, BD
    TUMMINO, PJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 210 : 22 - MEDI
  • [37] BEHAVIOR OF BETA,BETA-DICHLOROVINYL STYRYLKETONES IN ACID-MEDIUM - ATTEMPT TO SYNTHESIZE 5,6-DIHYDRO-4-HYDROXY-2-PYRONES
    BINETDUJASSONNEIX, C
    BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE PARTIE II-CHIMIE MOLECULAIRE ORGANIQUE ET BIOLOGIQUE, 1975, (3-4): : 758 - 769
  • [38] STRUCTURE-BASED, C2 SYMMETRICAL INHIBITORS OF HIV PROTEASE
    KEMPF, DJ
    NORBECK, DW
    CODACOVI, LM
    WANG, XC
    KOHLBRENNER, WE
    WIDEBURG, NE
    PAUL, DA
    KNIGGE, MF
    VASAVANONDA, S
    CRAIGKENNARD, A
    SALDIVAR, A
    ROSENBROOK, W
    CLEMENT, JJ
    PLATTNER, JJ
    ERICKSON, J
    JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (10) : 2687 - 2689
  • [39] ITERATIVE PROTEIN STRUCTURE-BASED DRUG DESIGN AND SYNTHESIS OF HIV PROTEASE INHIBITORS
    KALISH, V
    KALDOR, S
    SHETTY, B
    TATLOCK, J
    DAVIES, J
    HAMMOND, M
    DRESSMAN, B
    FRITZ, J
    APPELT, K
    REICH, S
    MUSICK, L
    WU, BW
    SU, K
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1995, 30 : S201 - S214
  • [40] Structure-based design of novel conformationally restricted HIV protease inhibitors.
    Rao, BG
    Baker, CT
    Court, JT
    Deininger, DD
    Kim, EE
    Li, B
    Novak, PM
    Salituro, FG
    Pazhanisamy, S
    Schairer, WC
    Tung, RD
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 214 : 51 - COMP
12345