Some pharmacological effects of the ethanol extract of leaves of Annona diversifolia on the central nervous system in mice

被引：1
|
作者：
González-Trujano, ME
Navarrete, A [1 ]
Reyes, B
Hong, E
机构：
[1] Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico
[2] Univ Autonoma Chapingo, Are Quim, Lab Prod Nat, Mexico City 56230, DF, Mexico
[3] CINVESTAV, IPN, Secc Terapeut Expt, Dept Farmacol & Toxicol, Mexico City 14000, DF, Mexico
来源：
PHYTOTHERAPY RESEARCH | 1998年 / 12卷 / 08期
关键词：
Annona diversifolia; CNS activity; anticonvulsant; Mexican traditional medicine;
D O I：
10.1002/(SICI)1099-1573(199812)12:8<600::AID-PTR363>3.0.CO;2-N
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the present study we investigated some neuropharmacological effects of the ethanol extract of the leaves of Annona diversifolia (Annonaceae). Intraperitoneal administration of the extract delayed the onset of clonic seizures induced by pentylenetetrazole and delayed the time in the 'rota-rod' and 'swimming' test. In addition, the extract augmented the duration of sleeping time induced by sodium pentobarbital. These results indicate that the ethanol extract of the leaves of A. diversifolia has depressant activity on the central nervous system. (C) 1998 John Wiley & Sons, Ltd.
引用
收藏
页码：600 / 602
页数：3
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