Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol

被引：11

作者：

Nakagawara, Kensuke ^{[1
]}

Namkoong, Ho ^{[2
]}

Terai, Hideki ^{[1
]}

Masaki, Katsunori ^{[1
]}

Tanosaki, Takae ^{[1
]}

Shimamoto, Kyoko ^{[3
]}

Lee, Ho ^{[1
]}

Tanaka, Hiromu ^{[1
]}

Okamori, Satoshi ^{[1
]}

Kabata, Hiroki ^{[1
]}

Chubachi, Shotaro ^{[1
]}

Ikemura, Shinnosuke ^{[1
]}

Kamata, Hirofumi ^{[1
]}

Yasuda, Hiroyuki ^{[1
]}

Kawada, Ichiro ^{[1
]}

Ishii, Makoto ^{[1
]}

Ishibashi, Yoshiki ^{[4
]}

Harada, Sei ^{[4
]}

Fujita, Takanori ^{[5
]}

Ito, Daisuke ^{[6
]}

Bun, Shogyoku ^{[7
]}

Tabuchi, Hajime ^{[7
]}

Kanzaki, Sho ^{[8
]}

Shimizu, Eisuke ^{[9
]}

Fukuda, Keitaro ^{[10
]}

Yamagami, Jun ^{[10
]}

Kobayashi, Keigo ^{[11
]}

Hirano, Toshiyuki ^{[11
]}

Inoue, Takashi ^{[11
]}

Kagyo, Junko ^{[12
]}

Shiomi, Tetsuya ^{[12
]}

Ohgino, Keiko ^{[13
]}

Sayama, Koichi ^{[13
]}

Otsuka, Kengo ^{[14
]}

Miyao, Naoki ^{[14
]}

Odani, Toshio ^{[15
]}

Oyamada, Yoshitaka ^{[16
]}

Masuzawa, Keita ^{[17
]}

Nakayama, Sohei ^{[17
]}

Suzuki, Yusuke ^{[17
]}

Baba, Rie ^{[18
]}

Nakachi, Ichiro ^{[18
]}

Kuwahara, Naota ^{[19
]}

Ishiguro, Takashi ^{[20
]}

Mashimo, Shuko ^{[21
]}

Minematsu, Naoto ^{[22
]}

Ueda, Soichiro ^{[23
]}

Manabe, Tadashi ^{[24
]}

Funatsu, Yohei ^{[24
]}

Koh, Hidefumi ^{[24
]}

机构：

[1] Keio Univ, Dept Med, Div Pulm Med, Sch Med, Tokyo, Japan

[2] Keio Univ, Dept Infect Dis, Sch Med, Tokyo, Japan

[3] Keio Univ, Keio Global Res Inst, Tokyo, Japan

[4] Keio Univ, Dept Prevent Med & Publ Hlth, Sch Med, Tokyo, Japan

[5] Keio Univ, Dept Hlth Policy & Management, Sch Med, Tokyo, Japan

[6] Keio Univ, Dept Neurol, Sch Med, Tokyo, Japan

[7] Keio Univ, Dept Neuropsychiat, Sch Med, Tokyo, Japan

[8] Keio Univ, Dept Otolaryngol, Sch Med, Tokyo, Japan

[9] Keio Univ, Dept Ophthalmol, Sch Med, Tokyo, Japan

[10] Keio Univ, Dept Dermatol, Sch Med, Tokyo, Japan

[11] Sano Kosei Gen Hosp, Dept Internal Med, Sano, Tochigi, Japan

[12] Keiyu Hosp, Dept Internal Med, Yokohama, Kanagawa, Japan

[13] Kawasaki Municipal Hosp, Div Pulm Med, Kawasaki, Kanagawa, Japan

[14] Nihon Koukan Hosp, Dept Internal Med, Kawasaki, Kanagawa, Japan

[15] Natl Hosp Org Hokkaido Med Ctr, Dept Rheumatol, Sapporo, Hokkaido, Japan

[16] Natl Hosp Org Tokyo Med Ctr, Dept Resp Med, Tokyo, Japan

[17] Kitasato Univ, Dept Resp Med, Kitasato Inst Hosp, Tokyo, Japan

[18] Saiseikai Utsunomiya Hosp, Dept Internal Med, Pulm Div, Utsunomiya, Tochigi, Japan

[19] Showa Univ, Dept Med, Div Allergol & Resp Med, Koto Toyosu Hosp, Tokyo, Japan

[20] Saitama Cardiovasc & Resp Ctr, Dept Resp Med, Saitama, Japan

[21] Toyohashi Municipal Hosp, Dept Resp Med, Toyohashi, Aichi, Japan

[22] Hino Municipal Hosp, Dept Internal Med, Tokyo, Japan

[23] Saitama Med Ctr, Dept Internal Med, Saitama, Japan

[24] Tachikawa Hosp, Dept Internal Med, Div Pulm Med, Tokyo, Japan

[25] Fukujuji Hosp, Resp Dis Ctr, Japan AntiTB Assoc, Tokyo, Japan

[26] Eiju Gen Hosp, Dept Pulm Med, Tokyo, Japan

[27] Saiseikai Cent Hosp, Dept Pulm Med, Tokyo, Japan

[28] Juntendo Univ, Dept Resp Med, Fac Med, Tokyo, Japan

[29] Grad Sch Med, Tokyo, Japan

[30] Ome Municipal Gen Hosp, Dept Resp Med, Tokyo, Japan

[31] Kawasaki Municipal Ida Hosp, Dept Pulm Med, Kawasaki, Kanagawa, Japan

[32] Saitama City Hosp, Dept Pulm Med, Saitama, Japan

[33] Osaka Univ, Dept Resp Med & Clin Immunol, Grad Sch Med, Osaka, Japan

[34] Fukuoka Tokushukai Hosp, Dept Gen Internal Med, Fukuoka, Japan

[35] Kurume Univ, Dept Internal Med, Div Respirol Neurol & Rheumatol, Sch Med, Fukuoka, Japan

[36] Int Univ Hlth & Welf, Dept Resp Med, Shioya Hosp, Otawara, Tochigi, Japan

[37] Keio Univ Hosp, Clin & Translat Res Ctr, Tokyo, Japan

[38] Keio Univ, Dept Organoid Med, Sch Med, Tokyo, Japan

[39] Keio Univ Hosp, Clin & Translat Res Ctr, Biostat Unit, Tokyo, Japan

[40] Keio Univ, Grad Sch Business Adm, Tokyo, Japan

[41] Keio Univ, Fac Econ, Tokyo, Japan

[42] Keio Univ, Sch Med, Div Gastroenterol & Hepatol, Dept Internal Med, Tokyo, Japan

来源：

BMJ OPEN RESPIRATORY RESEARCH | 2021年 / 8卷 / 01期

关键词：

SLEEP QUALITY; DEPRESSION; DYSPNEA; COUNCIL; DISEASE; HEALTH;

D O I：

10.1136/bmjresp-2021-001015

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Introduction The rapid spread of COVID-19 posed a global burden. Substantial number of people died of the disease in the acute phase of infection. In addition, a significant proportion of patients have been reported to suffer from post-acute phase symptoms, sequelae of COVID-19, which may negatively influence the quality of daily living and/or socioeconomic circumstances of the patients. However, no previous study has comprehensively and objectively assessed the quality of life of patients by using existing international scales. Further, evidence of socioeconomic consequences among patients with COVID-19 is scarce. To address the multidimensional issues from sequelae of COVID-19, evidence from comprehensive surveys beyond clinical perspectives is critical that investigates health, and social determinants of disease progression as well as socioeconomic consequences at a large scale. Methods and analysis In this study, we plan to conduct a nationwide and comprehensive survey for the sequelae of COVID-19 in a total of 1000 patients diagnosed at 27 hospitals throughout Japan. This study will evaluate not only the health-related status of patients from clinical perspectives but also the Health-related Quality of Life (HRQoL) scores, socioeconomic status and consequences to discuss the sequelae of the disease and the related risk factors. The primary endpoint is the frequency of long-term complications of COVID-19 infection. The secondary endpoints are risk factors for progression to sequelae of COVID-19 infection. The study will provide robust and important evidence as a resource to tackle the issues from the sequelae of COVID-19 from the multi-dimensional perspectives. Ethics and dissemination This trial was approved by the Keio University School of Medicine Ethics Committee (20200243, UMIN000042299). The results of this study will be reported at a society meeting or published in a peer-reviewed journal.

引用

页数：9

共 50 条

[41] Long-term post-acute sequelae of COVID-19 infection: a retrospective, multi-database cohort study in Hong Kong and the UK
Lam, Ivan Chun Hang
Wong, Carlos King Ho
Zhang, Ran
Chui, Celine Sze Ling
Lai, Francisco Tsz Tsun
Li, Xue
Chan, Esther Wai Yin
Luo, Hao
Zhang, Qingpeng
Man, Kenneth Keng Cheung
Cheung, Bernard Man Yung
Tang, Sydney Chi Wai
Lau, Chak Sing
Wan, Eric Yuk Fai
Wong, Ian Chi Kei
ECLINICALMEDICINE, 2023, 60
[42] Cardiopulmonary Long-Term Sequelae in Patients after Severe COVID-19 Disease
Niebauer, Julia Hanne
Binder-Rodriguez, Christina
Iscel, Ahmet
Schedl, Sarah
Capelle, Christophe
Kahr, Michael
Cadjo, Simona
Schamilow, Simon
Badr-Eslam, Roza
Lichtenauer, Michael
Toma, Aurel
Zoufaly, Alexander
Valenta, Rosmarie
Hoffmann, Sabine
Charwat-Resl, Silvia
Krestan, Christian
Hitzl, Wolfgang
Wenisch, Christoph
Bonderman, Diana
JOURNAL OF CLINICAL MEDICINE, 2023, 12 (04)
[43] LONG-TERM COVID-19 SEQUELAE: OMICRON VERSUS ALPHA AND DELTA VARIANTS
Hernandez Aceituno, A.
Garcia Hernandez, A.
Larumbe Zabala, E.
GACETA SANITARIA, 2023, 37 : S185 - S185
[44] A Systematic Review and Quality Evaluation of Studies on Long-Term Sequelae of COVID-19
Vasconez-Gonzalez, Jorge
Izquierdo-Condoy, Juan S.
Fernandez-Naranjo, Raul
Ortiz-Prado, Esteban
HEALTHCARE, 2022, 10 (12)
[45] COVID-19 long-term sequelae: Omicron versus Alpha and Delta variants
Hernandez-Aceituno, Ana
Garcia-Hernandez, Abigail
Larumbe-Zabala, Eneko
INFECTIOUS DISEASES NOW, 2023, 53 (05):
[46] Cardiopulmonary disease as sequelae of long-term COVID-19: Current perspectives and challenges
Oliveira, Rudolf K. F.
Nyasulu, Peter S.
Iqbal, Adeel Ahmed
Gul, Muhammad Hamdan
Ferreira, Eloara V. M.
Leclair, John William
Htun, Zin Mar
Howard, Luke S.
Mocumbi, Ana O.
Bryant, Andrew J.
Tamuzi, Jacques L.
Avdeev, Sergey
Petrosillo, Nicola
Hassan, Ahmed
Butrous, Ghazwan
Perez, Vinicio de Jesus
FRONTIERS IN MEDICINE, 2022, 9
[47] Is There a Role for Hyperbaric Oxygen Therapy in Reducing Long-Term COVID-19 Sequelae?
Oliaei, Shahram
Paranjkhoo, Parinaz
SeyedAlinaghi, SeyedAhmad
Mehraeen, Esmaeil
Hackett, Daniel
JOURNAL OF CLINICAL MEDICINE, 2023, 12 (06)
[48] Study Protocol for a Cross-Sectional Survey on the Long-Term Impact of COVID-19 on Latino Health
Baquerizo, Humberto
Acevedo, Sebastian
Malarkey, Sarah
Lewis, Kendra
Valera, Pamela
JOURNAL OF LATINOS AND EDUCATION, 2024,
[49] Nutritional practice in critically ill COVID-19 patients: A multicenter ambidirectional cohort study in Wuhan and Jingzhou
Lin, Jiajia
Ke, Lu
Doig, Gordon S.
Ye, Bo
Jiang, Zhengying
Liu, Zhiyong
Guo, Feng
Yin, Jiangtao
Yu, Wenkui
Sun, Jiakui
Sun, Liqun
Ding, Renyu
Xu, Hongyang
Chang, Zhigang
Long, Yi
Qian, Yajun
Tong, Zhihui
Li, Weiqin
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION, 2021, 30 (01) : 15 - 21
[50] Specific sequelae symptoms of COVID-19 of Omicron variant in comparison with non-COVID-19 patients: a retrospective cohort study in Japan
Omori, Takahiro
Hanafusa, Mariko
Kondo, Nobuyuki
Miyazaki, Yasunari
Okada, Shusho
Fujiwara, Takeo
Kuramochi, Jin
JOURNAL OF THORACIC DISEASE, 2024, 16 (05) : 3170 - +

← 1 2 3 4 5 →