Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol

被引：11

作者：

Nakagawara, Kensuke ^{[1
]}

Namkoong, Ho ^{[2
]}

Terai, Hideki ^{[1
]}

Masaki, Katsunori ^{[1
]}

Tanosaki, Takae ^{[1
]}

Shimamoto, Kyoko ^{[3
]}

Lee, Ho ^{[1
]}

Tanaka, Hiromu ^{[1
]}

Okamori, Satoshi ^{[1
]}

Kabata, Hiroki ^{[1
]}

Chubachi, Shotaro ^{[1
]}

Ikemura, Shinnosuke ^{[1
]}

Kamata, Hirofumi ^{[1
]}

Yasuda, Hiroyuki ^{[1
]}

Kawada, Ichiro ^{[1
]}

Ishii, Makoto ^{[1
]}

Ishibashi, Yoshiki ^{[4
]}

Harada, Sei ^{[4
]}

Fujita, Takanori ^{[5
]}

Ito, Daisuke ^{[6
]}

Bun, Shogyoku ^{[7
]}

Tabuchi, Hajime ^{[7
]}

Kanzaki, Sho ^{[8
]}

Shimizu, Eisuke ^{[9
]}

Fukuda, Keitaro ^{[10
]}

Yamagami, Jun ^{[10
]}

Kobayashi, Keigo ^{[11
]}

Hirano, Toshiyuki ^{[11
]}

Inoue, Takashi ^{[11
]}

Kagyo, Junko ^{[12
]}

Shiomi, Tetsuya ^{[12
]}

Ohgino, Keiko ^{[13
]}

Sayama, Koichi ^{[13
]}

Otsuka, Kengo ^{[14
]}

Miyao, Naoki ^{[14
]}

Odani, Toshio ^{[15
]}

Oyamada, Yoshitaka ^{[16
]}

Masuzawa, Keita ^{[17
]}

Nakayama, Sohei ^{[17
]}

Suzuki, Yusuke ^{[17
]}

Baba, Rie ^{[18
]}

Nakachi, Ichiro ^{[18
]}

Kuwahara, Naota ^{[19
]}

Ishiguro, Takashi ^{[20
]}

Mashimo, Shuko ^{[21
]}

Minematsu, Naoto ^{[22
]}

Ueda, Soichiro ^{[23
]}

Manabe, Tadashi ^{[24
]}

Funatsu, Yohei ^{[24
]}

Koh, Hidefumi ^{[24
]}

机构：

[1] Keio Univ, Dept Med, Div Pulm Med, Sch Med, Tokyo, Japan

[2] Keio Univ, Dept Infect Dis, Sch Med, Tokyo, Japan

[3] Keio Univ, Keio Global Res Inst, Tokyo, Japan

[4] Keio Univ, Dept Prevent Med & Publ Hlth, Sch Med, Tokyo, Japan

[5] Keio Univ, Dept Hlth Policy & Management, Sch Med, Tokyo, Japan

[6] Keio Univ, Dept Neurol, Sch Med, Tokyo, Japan

[7] Keio Univ, Dept Neuropsychiat, Sch Med, Tokyo, Japan

[8] Keio Univ, Dept Otolaryngol, Sch Med, Tokyo, Japan

[9] Keio Univ, Dept Ophthalmol, Sch Med, Tokyo, Japan

[10] Keio Univ, Dept Dermatol, Sch Med, Tokyo, Japan

[11] Sano Kosei Gen Hosp, Dept Internal Med, Sano, Tochigi, Japan

[12] Keiyu Hosp, Dept Internal Med, Yokohama, Kanagawa, Japan

[13] Kawasaki Municipal Hosp, Div Pulm Med, Kawasaki, Kanagawa, Japan

[14] Nihon Koukan Hosp, Dept Internal Med, Kawasaki, Kanagawa, Japan

[15] Natl Hosp Org Hokkaido Med Ctr, Dept Rheumatol, Sapporo, Hokkaido, Japan

[16] Natl Hosp Org Tokyo Med Ctr, Dept Resp Med, Tokyo, Japan

[17] Kitasato Univ, Dept Resp Med, Kitasato Inst Hosp, Tokyo, Japan

[18] Saiseikai Utsunomiya Hosp, Dept Internal Med, Pulm Div, Utsunomiya, Tochigi, Japan

[19] Showa Univ, Dept Med, Div Allergol & Resp Med, Koto Toyosu Hosp, Tokyo, Japan

[20] Saitama Cardiovasc & Resp Ctr, Dept Resp Med, Saitama, Japan

[21] Toyohashi Municipal Hosp, Dept Resp Med, Toyohashi, Aichi, Japan

[22] Hino Municipal Hosp, Dept Internal Med, Tokyo, Japan

[23] Saitama Med Ctr, Dept Internal Med, Saitama, Japan

[24] Tachikawa Hosp, Dept Internal Med, Div Pulm Med, Tokyo, Japan

[25] Fukujuji Hosp, Resp Dis Ctr, Japan AntiTB Assoc, Tokyo, Japan

[26] Eiju Gen Hosp, Dept Pulm Med, Tokyo, Japan

[27] Saiseikai Cent Hosp, Dept Pulm Med, Tokyo, Japan

[28] Juntendo Univ, Dept Resp Med, Fac Med, Tokyo, Japan

[29] Grad Sch Med, Tokyo, Japan

[30] Ome Municipal Gen Hosp, Dept Resp Med, Tokyo, Japan

[31] Kawasaki Municipal Ida Hosp, Dept Pulm Med, Kawasaki, Kanagawa, Japan

[32] Saitama City Hosp, Dept Pulm Med, Saitama, Japan

[33] Osaka Univ, Dept Resp Med & Clin Immunol, Grad Sch Med, Osaka, Japan

[34] Fukuoka Tokushukai Hosp, Dept Gen Internal Med, Fukuoka, Japan

[35] Kurume Univ, Dept Internal Med, Div Respirol Neurol & Rheumatol, Sch Med, Fukuoka, Japan

[36] Int Univ Hlth & Welf, Dept Resp Med, Shioya Hosp, Otawara, Tochigi, Japan

[37] Keio Univ Hosp, Clin & Translat Res Ctr, Tokyo, Japan

[38] Keio Univ, Dept Organoid Med, Sch Med, Tokyo, Japan

[39] Keio Univ Hosp, Clin & Translat Res Ctr, Biostat Unit, Tokyo, Japan

[40] Keio Univ, Grad Sch Business Adm, Tokyo, Japan

[41] Keio Univ, Fac Econ, Tokyo, Japan

[42] Keio Univ, Sch Med, Div Gastroenterol & Hepatol, Dept Internal Med, Tokyo, Japan

来源：

BMJ OPEN RESPIRATORY RESEARCH | 2021年 / 8卷 / 01期

关键词：

SLEEP QUALITY; DEPRESSION; DYSPNEA; COUNCIL; DISEASE; HEALTH;

D O I：

10.1136/bmjresp-2021-001015

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Introduction The rapid spread of COVID-19 posed a global burden. Substantial number of people died of the disease in the acute phase of infection. In addition, a significant proportion of patients have been reported to suffer from post-acute phase symptoms, sequelae of COVID-19, which may negatively influence the quality of daily living and/or socioeconomic circumstances of the patients. However, no previous study has comprehensively and objectively assessed the quality of life of patients by using existing international scales. Further, evidence of socioeconomic consequences among patients with COVID-19 is scarce. To address the multidimensional issues from sequelae of COVID-19, evidence from comprehensive surveys beyond clinical perspectives is critical that investigates health, and social determinants of disease progression as well as socioeconomic consequences at a large scale. Methods and analysis In this study, we plan to conduct a nationwide and comprehensive survey for the sequelae of COVID-19 in a total of 1000 patients diagnosed at 27 hospitals throughout Japan. This study will evaluate not only the health-related status of patients from clinical perspectives but also the Health-related Quality of Life (HRQoL) scores, socioeconomic status and consequences to discuss the sequelae of the disease and the related risk factors. The primary endpoint is the frequency of long-term complications of COVID-19 infection. The secondary endpoints are risk factors for progression to sequelae of COVID-19 infection. The study will provide robust and important evidence as a resource to tackle the issues from the sequelae of COVID-19 from the multi-dimensional perspectives. Ethics and dissemination This trial was approved by the Keio University School of Medicine Ethics Committee (20200243, UMIN000042299). The results of this study will be reported at a society meeting or published in a peer-reviewed journal.

引用

页数：9

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