Rhein promotes TRAIL-induced apoptosis in bladder cancer cells by up-regulating DR5 expression

被引：7
|
作者：
Ma, Liang [1 ,2 ]
Wei, Hong-Ling [3 ,4 ]
Wang, Ke-Jie [3 ,4 ]
Meng, Xiang-Yu [3 ,4 ]
Ni, Sai-Qi [3 ,4 ]
Zhou, Cheng [5 ]
Li, Yi [6 ]
Yu, Rui [1 ]
Ma, Qi [2 ,3 ,4 ,5 ]
机构：
[1] Ningbo Univ, Med Sch, Ningbo 315211, Zhejiang, Peoples R China
[2] Ningbo Univ, Ningbo Hosp 1, Comprehens Urogenital Canc Ctr, Affiliated Hosp, Ningbo 315010, Zhejiang, Peoples R China
[3] Ningbo Univ, Ningbo Hosp 1, Translat Res Lab Urol, Key Lab Ningbo City,Affiliated Hosp, Ningbo 315010, Zhejiang, Peoples R China
[4] Ningbo Clin Res Ctr Urol Dis, Ningbo 315010, Zhejiang, Peoples R China
[5] Ningbo Univ, Ningbo Hosp 1, Dept Urol, Affiliated Hosp, Ningbo 315010, Zhejiang, Peoples R China
[6] Zhejiang Univ, Affiliated Hosp 2, Dept Urol, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China
来源：
AGING-US | 2022年 / 14卷 / 16期
关键词：
bladder cancer; drug resistance; Rhein; TRAIL; DR5; DEATH RECEPTORS; TNF-FAMILY; KAPPA-B; RESISTANCE; LIGAND; SUPPRESSION; STATISTICS; MECHANISMS; CARCINOMA;
D O I：
10.18632/aging.204236
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) combined with sensitizer is a potential method to reverse TRAIL-resistance in tumor cells. Rhein (RH) is a monomer extracted from Chinese herbs that has been reported to show anti-tumor effects in a variety of tumor cells, but the role of RH in TRAIL-induced anti-tumor effects in bladder cancer cells has not been reported. In this study, we found that the combined treatment of a non-toxic concentration of RH with TRAIL significantly inhibited the proliferation and induced apoptosis in both TRAIL sensitive and resistant bladder cancer cell lines. Furthermore, we found that RH promoted bladder cancer cell apoptosis by up-regulating DR5 expression. Our findings provide potential value in the clinical treatment of bladder cancer.
引用
收藏
页码：6642 / 6655
页数：14
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