Rhein promotes TRAIL-induced apoptosis in bladder cancer cells by up-regulating DR5 expression

被引：7
|
作者：
Ma, Liang [1 ,2 ]
Wei, Hong-Ling [3 ,4 ]
Wang, Ke-Jie [3 ,4 ]
Meng, Xiang-Yu [3 ,4 ]
Ni, Sai-Qi [3 ,4 ]
Zhou, Cheng [5 ]
Li, Yi [6 ]
Yu, Rui [1 ]
Ma, Qi [2 ,3 ,4 ,5 ]
机构：
[1] Ningbo Univ, Med Sch, Ningbo 315211, Zhejiang, Peoples R China
[2] Ningbo Univ, Ningbo Hosp 1, Comprehens Urogenital Canc Ctr, Affiliated Hosp, Ningbo 315010, Zhejiang, Peoples R China
[3] Ningbo Univ, Ningbo Hosp 1, Translat Res Lab Urol, Key Lab Ningbo City,Affiliated Hosp, Ningbo 315010, Zhejiang, Peoples R China
[4] Ningbo Clin Res Ctr Urol Dis, Ningbo 315010, Zhejiang, Peoples R China
[5] Ningbo Univ, Ningbo Hosp 1, Dept Urol, Affiliated Hosp, Ningbo 315010, Zhejiang, Peoples R China
[6] Zhejiang Univ, Affiliated Hosp 2, Dept Urol, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China
来源：
AGING-US | 2022年 / 14卷 / 16期
关键词：
bladder cancer; drug resistance; Rhein; TRAIL; DR5; DEATH RECEPTORS; TNF-FAMILY; KAPPA-B; RESISTANCE; LIGAND; SUPPRESSION; STATISTICS; MECHANISMS; CARCINOMA;
D O I：
10.18632/aging.204236
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) combined with sensitizer is a potential method to reverse TRAIL-resistance in tumor cells. Rhein (RH) is a monomer extracted from Chinese herbs that has been reported to show anti-tumor effects in a variety of tumor cells, but the role of RH in TRAIL-induced anti-tumor effects in bladder cancer cells has not been reported. In this study, we found that the combined treatment of a non-toxic concentration of RH with TRAIL significantly inhibited the proliferation and induced apoptosis in both TRAIL sensitive and resistant bladder cancer cell lines. Furthermore, we found that RH promoted bladder cancer cell apoptosis by up-regulating DR5 expression. Our findings provide potential value in the clinical treatment of bladder cancer.
引用
收藏
页码：6642 / 6655
页数：14
相关论文
共 50 条
  • [21] BIX-01294 sensitizes renal cancer Caki cells to TRAIL-induced apoptosis through downregulation of survivin expression and upregulation of DR5 expression
    Woo, Seon Min
    Seo, Seung Un
    Min, Kyoung-Jin
    Kwon, Taeg Kyu
    CELL DEATH DISCOVERY, 2018, 4
  • [22] Triptolide sensitizes TRAIL-induced apoptosis in prostate cancer cells via p53-mediated DR5 up-regulation
    Hu Xiaowen
    Sun Yi
    MOLECULAR BIOLOGY REPORTS, 2012, 39 (09) : 8763 - 8770
  • [23] Triptolide sensitizes TRAIL-induced apoptosis in prostate cancer cells via p53-mediated DR5 up-regulation
    Hu Xiaowen
    Sun Yi
    Molecular Biology Reports, 2012, 39 : 8763 - 8770
  • [24] Inostamycin enhanced TRAIL-induced apoptosis through DR5 upregulation on the cell surface
    Yamamoto, Kohta
    Makino, Masafumi
    Watanapokasin, Ramida
    Tashiro, Etsu
    Imoto, Masaya
    JOURNAL OF ANTIBIOTICS, 2012, 65 (06): : 295 - 300
  • [25] Inostamycin enhanced TRAIL-induced apoptosis through DR5 upregulation on the cell surface
    Kohta Yamamoto
    Masafumi Makino
    Ramida Watanapokasin
    Etsu Tashiro
    Masaya Imoto
    The Journal of Antibiotics, 2012, 65 : 295 - 300
  • [26] Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5
    Yang Li
    Xing Fan
    C Rory Goodwin
    John Laterra
    Shuli Xia
    BMC Cancer, 8
  • [27] 20(s)-ginsenoside Rh2 promotes TRAIL-induced apoptosis by upregulating DR5 in human hepatocellular carcinoma cells
    Wenmo Liu
    Siqi Wang
    Qinchuan Yang
    Xinyao Feng
    Bin Yu
    Xianghui Yu
    Medical Oncology, 39
  • [28] Artonin E sensitizes TRAIL-induced apoptosis by DR5 upregulation and cFLIP downregulation in TRAIL-refractory colorectal cancer LoVo cells
    Sophonnithiprasert, Thanet
    Mahabusarakam, Wilawan
    Watanapokasin, Ramida
    JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2019, 10 (02) : 209 - 217
  • [29] Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5
    Li, Yang
    Fan, Xing
    Goodwin, C. Rory
    Laterra, John
    Xia, Shuli
    BMC CANCER, 2008, 8 (1)
  • [30] 20(s)-ginsenoside Rh2 promotes TRAIL-induced apoptosis by upregulating DR5 in human hepatocellular carcinoma cells
    Liu, Wenmo
    Wang, Siqi
    Yang, Qinchuan
    Feng, Xinyao
    Yu, Bin
    Yu, Xianghui
    MEDICAL ONCOLOGY, 2022, 39 (05)
12345